Correlation between systemic inflammatory response index and short-term prognosis in patients with Guillain-Barre
syndrome Hu Yingying，Zhao Wenyan，Zhou Yuliang，Xu Zhipeng． Department of Neurology，Zhongnan Hospital of Wuhan
University，Hubei Province，Wuhan 430062，China
Corresponding author: Xu Zhipeng，E-mail: xzhp14@ sina． com
Funding program: Key Ｒ＆D Plan of Hubei Province ( 2022BCA039)
【Abstract】 Objective To analyze the correlation between systemic inflammatory response index ( SIＲI) and short-
term prognosis in patients with Guillain-Barre syndrome ( GBS) ． Method One hundred and six patients with GBS were se-
lected from the Department of Neurology，Central South Hospital，Wuhan University from January 2014 to July 2022． Accord-
ing to the Hughes functional grading ( HFGS) ，76 patients were divided into the group with good prognosis ( HFGS score ＜ 4)
and 30 patients with poor prognosis ( HFGS score ≥ 4) ． The clinical data and inflammatory response indicators ( neutrophil
count，lymphocyte count，monocyte count，platelet count，SIＲI) of the two groups were compared． The Spearman method was
used to analyze the correlation between HFGS score and inflammatory response index of GBS patients at discharge，and the di-
agnostic value of inflammatory response index on short-term poor prognosis of GBS patients was evaluated by the subject work
characteristic curve ( ＲOC) ，and the influencing factors of short-term poor prognosis of GBS patients were analyzed by multi-
variate logistic regression． Ｒesults The proportion of dyspnea and blood glucose level in patients with poor prognosis were
higher than those in patients with good prognosis，while the serum albumin level was lower than those in patients with good
prognosis ( P ＜ 0． 05) ． The neutrophil count，monocyte count and SIＲI in the poor prognosis group were higher than those in
·662· 疑难病杂志 2023 年 3 月第 22 卷第 3 期 Chin J Diffic and Compl Cas，March 2023，Vol． 22，No． 3

the good prognosis group，while the lymphocyte count was lower than those in the good prognosis group ( Z / P = 5． 552 / ＜ 0．
001，4． 493 / ＜ 0． 001，5． 982 / ＜ 0． 001，2． 441 /0． 015) ． The HFGS score of GBS patients at discharge was positively correla-
ted with neutrophil count，monocyte count and SIＲI ( r = 0． 566，0． 502，0． 708，P ＜ 0． 001) ，and negatively correlated with
lymphocyte count ( r = － 0． 397，P ＜ 0． 001) ． The area under the curve ( AUC) of neutrophil count，monocyte count，SIＲI
and their combination to predict the poor prognosis of GBS were 0． 847，0． 781，0． 874 and 0． 870，respectively． SIＲI was
more effective in predicting short － term poor prognosis of GBS than monocyte count( Z / P = 2． 408 /0． 016) ，and there was no
significant difference between it and neutrophil count or their combination( Z / P = 0． 855 /0． 392、0． 248 /0． 804) ． Logistic re-
gression analysis showed that the increase of SIＲI at admission and dyspnea during hospitalization were independent risk factors
for poor short-term prognosis of GBS patients ［OＲ ( 95% CI) = 1． 565 ( 1． 167 － 2． 098) ，6． 034 ( 1． 568 － 23． 218) ］． Con-
clusion The increase of SIＲI in GBS patients at admission and dyspnea during hospitalization suggest poor short-term progno-
sis． SIＲI can be used as a potential biomarker for short-term prognosis of GBS patients．
【Key words】 Guillain-Barré syndrome; Systemic inflammatory response index; Dyspnea; Prognosis; Correlation