Abstract:Objective To explore the effects of three-dimensional digital subtraction angiography(3D-DSA)-guided neurointerventional thrombectomy on brachial-ankle pulse wave velocity(ba-PWV) and serum Netrin-1 in patients with ischemic stroke(IS).Methods From September 2021 to November 2024, totally 180 patients with IS who received treatment in Department of Neurology, Jiangsu Province Hospital/The First Affiliated Hospital with Nanjing Medical University were served as the research subjects and assigned into two groups through the random number table method: thrombolysis group(intravenous thrombolysis) and thrombectomy group(intravenous thrombolysis + 3D-DSA-guided neurointerventional thrombectomy). The vascular recanalization rate, ba-PWV, neurological function, cerebral hemodynamics, serum indicators [ neuron specific enolase(NSE), Netrin-1], and adverse reactions were compared.Results The vascular recanalization rate in the thrombectomy group was 94.44%, which was higher than the 83.33% in the thrombolysis group(χ ²/P=5.625/0.018). After treatment, the thrombectomy group had lower ba-PWV, neurological function score, peripheral resistance(Rv), and NSE(t/P=7.327/<0.001,16.857/<0.001,6.630/<0.001,8.480/<0.001), and higher Netrin-1 and mean cerebral blood flow(Qm) than the thrombolysis group(t/P=4.905/<0.001,4.598/<0.001).There was no prominent difference in adverse reactions between two groups(χ ²/P=0.669/0.414).Conclusion The 3D-DSA-guided neurointerventional thrombectomy can improve vascular recanalization rate, cerebral hemodynamics, reduce the risk of IS recurrence, upregulate Netrin-1 level, inhibit NSE expression, reduce brain injury, and improve neurological function in patients with IS.