Research progress on biological functions of SUV39H1
Author:Jian Jun,Liu Xiuheng,Wang Lei.
keyword:SUV39H1; H3K9 methylation; Human histone lysine methyltransferase; Epigenetic modification
SUV39 H1 is the first human histone lysine methyltransferase(HMT) discovered, which can specifically methylate H3 K9, participate in the formation of heterochromatin and gene silencing, and then play an epigenetic role in regulation. Recent studies have found that SUV39 H1 has both anti-tumor and carcinogenic effects, and plays an important role in the regulation of tumor occurrence and development. In addition, abnormal expression of SUV39 H1 was found in many disease processes, indicating that it is widely involved in various pathophysiological processes. This article reviews the research on the relationship between SUV39 H1 and various disease processes in recent years, summarizes the regulation mechanism of SUV39 H1 in the process of growth, development and disease occurrence and development, and provides new ideas for the diagnosis and treatment of related diseases.