Objective To analyze the relationship between peripheral blood fulin(Furin), soluble tumor necrosis factor like weak apoptotic inducer(sTWEAK), neutrophil/lymphocyte ratio(NLR), myocardial injury indicators, and poor prognosis in patients with type H hypertension(HHT) and acute myocardial infarction(AMI). Methods Two hundred and thirty-one patients with HHT and AMI treated in the Cardiovascular Department of Fangshan Hospital, Beijing University of Chinese Medicine from January 2019 to February 2021 were selected as the HHT+AMI group, 77 patients with HHT only were selected as the HHT group, and 52 healthy examinees from the hospital were selected as the healthy control group. The peripheral blood levels of Furin, sTWEAK, NLR, and serum myocardial injury indicators [creatine kinase isoenzyme(CK-MB), cardiac troponin I(cTnI), N-terminal pro-brain natriuretic peptide(NT-proBNP)] were compared among the three groups, and the correlation between peripheral blood levels of Furin, sTWEAK, NLR, and myocardial injury indicators was analyzed. The main adverse cardiovascular events(MACE) in the HHT+AMI group were recorded during a 1-year follow-up, and logistic regression was used to analyze the factors influencing the occurrence of MACE in HHT+AMI patients. The receiver operating characteristic(ROC) curve was plotted to analyze the predictive value of the three factors for MACE in HHT+AMI patients. Results Comparison of peripheral blood Furin, sTWEAK, and NLR levels in HHT+AMI group>HHT group>healthy control group(F/P=981.029/<0.001, 1 032.486/<0.001, 326.617/<0.001), and MACE subgroup was higher than non MACE subgroup(t/P=19.498/<0.001, 17.909/<0.001, 2.507/<0.001); The levels of CK-MB in HHT+AMI group were higher than those in HHT group and healthy control group, and the levels of serum cTnI and NT-proBNP in HHT+AMI group were higher than those in HHT group and healthy control group(F/P=580.966/<0.001, 672.830/<0.001, 463.233/<0.001); Peripheral blood Furin, sTWEAK, and NLR were significantly positively correlated with serum CK-MB, cTnI, and NT-proBNP(Furin: r/P=0.713/<0.001, 0.604/<0.001, 0.515/<0.001; sTWEAK:r/P=0.412/0.002, 0.533/<0.001, 0.502/<0.001; NLR:r/P=0.513/<0.001, 0.554/<0.001, 0.481/<0.001); Killip III/IV, high Gensini score, high Furin, high sTWEAK, and high NLR are independent risk factors for MACE in patients with HHT and AMI [OR(95%CI)=1.725(1.178 to 2.524), 1.571(1.160 to 2.128), 2.412(1.527 to 3.806), 2.204(1.421 to 3.418), 1.784(1.213 to 2.624)]. The area under the curve(AUC) of peripheral blood Furin, sTWEAK, NLR, and their combined detection in predicting MACE in patients with HHT and AMI were 0.740, 0.715, 0.693, and 0.841, respectively. The combined prediction efficacy of the three indicators was better than that of each indicator alone(Z/P=2.038/0.042, 2.459/0.014, 4.037/<0.001). Conclusion Furin, sTWEAK, and NLR are abnormally elevated in the peripheral blood of patients with HHT and AMI, and are closely related to myocardial injury and poor prognosis. The combined detection of the three can be used as a reference basis for predicting poor prognosis in patients with HHT and AMI.

H-type hypertension;                    Myocardial infarction,acute;                    Furin;                    Soluble tumor necrosis factor like weak apoptosis inducing factor;                    Neutrophil/lymphocyte ratio;                    Myocardial injury index;                    Prognosis;