Transmembrane emp24 domain-containing protein(TMED) family, as a kind of transmembrane protein whose molecular weight is 24KDa, plays important roles in many aspects, such as early embryonic development, organ formation, innate immune signaling, cell proliferation and so on. In recent years, people have focused a lot on researches applications of TMED family in treating malignant tumor and its abnormal expressions are closely related to the occurrence, development, invasion, metastasis and prognosis of tumors. Recent researches have shown that TMED has expressions of different degrees in different malignant tumors, including breast cancer, liver cancer, ovarian cancer, colorectal cancer, cervical cancer, etc. It has a very complex mechanism in promoting tumor development. This thesis discusses the current research situations of the application of TMED in treating malignant tumors and its operational mechanism, contributing to the groundwork for the prevention and treatment.

In recent years, the incidence of some neurological diseases such as Alzheimer's disease, depression and schizophrenia have increased significantly, which has attracted some scholars' attention. Subsequent studies have found that androgens may have protective effects on male nerve cells such as reducing inflammation and anti-oxidative stress. In addition, some clinical trial results also show that androgens can improve cognitive function and alleviate depressive symptoms in some neurological diseases, such as male Alzheimer's disease and depression. Therefore, scholars have explored the possible neuroprotective mechanism of androgens in males. This article reviews the research progress of androgens on the neuroprotective mechanism of males.

Alzheimer's disease is a disease with progressive cognitive impairment as the core. In recent years, studies have shown that the incidence of Alzheimer's disease is closely related to systematic factors, which coincides with the overall concept of traditional Chinese medicine, and also provides a good opportunity for the development and integration of Chinese and Western medicine. "Qi and blood theory" is the cornerstone of the theoretical framework of traditional Chinese medicine. This paper will take "Qi and blood" as the starting point, sort out the pathogenesis of Alzheimer's disease from the overall perspective of China and the West, and deeply analyze the scientific connotation of the pathogenesis of Alzheimer's disease, in order to provide new ideas for clinical prevention and treatment of Alzheimer's disease.