Ｒesearch progress on the role of GSDM family proteins in pyrodeath of cells Ye Chenglin
Pyroptosis, as an inflammatory regulatory cell death, plays an important role in the process of organism's defense against foreign pathogens as well as other disease. The specific mechanism of pyroptosis through Caspase activation has made breakthrough progress in recent years. GSDMD protein, as a Caspase substrate, cleaved and perforated the cell membrane to induce pyroptosis. The role of other GSDMs family proteins in pyroptosis has also been gradually elucidated. Pyroptosis has been recognized as a programmed death process mediated by GSDM family proteins.