Pyroptosis, a form of programmed cell death activated by Caspase, plays an important role in the development and progression of diabetes and its complications. Chinese medicine has unique advantages such as multiple pathways and multiple targets, and how to effectively prevent and treat diabetes and its complications with the theory of pyroptosis is a current scientific research hotspot. In this paper, we summarize the role of pyroptosis in diabetes, diabetic nephropathy, diabetic cardiomyopathy and other complications from the pyroptosis and Chinese medicine, and summarize and organize the effective components of Chinese medicine, such as ginsenoside Rb1, Emodin, mechanism of Huanglian WendanTang and Jiawei Shengjiangsan, which can prevent and treat diabetes and its complications by targeting pyroptosis, and provide a basis for future research. This will provide a theoretical basis and research direction for the future application of TCM in the prevention and treatment of diabetes and its complications.

Periodontitis is a complex chronic disease that involves various factors such as bacteria, host immunity, genetics, and environment. So far, the early diagnosis and monitoring of periodontitis mostly rely on the measurement of clinical parameters, but it has a certain degree of lag and subjectivity. With the continuous development of salivary omics, research has found that saliva is a potential biomarker repository. The collection of saliva samples is non-invasive and can prevent the spread of the virus, which is expected to become a substitute for blood. As an important biomarker, many cytokines in saliva participate in the recruitment of specific immune cells, the control of pathogens and the induction or inhibition of osteoclast activity. Therefore, this article provides a review of the most valuable cytokines in saliva for the early diagnosis of periodontitis.