Objective To explore the effect of zingerone(ZGR) on the myocardium of rats after acute myocardial infarction.Methods The experiment was conducted at the Institute of Cardiovascular Disease, People's Hospital, Wuhan University from July to September 2022. Thirty male SPF grade SD rats were randomly divided into Sham group, MI group, and MI+ZGR group using a number table method, with 10 rats in each group. The MI+ZGR group and MI group were treated with ZGR(6 mg·kg-1·d-1) and an equal amount of physiological saline by gavage for 21 days, respectively. On the 14th day of drug treatment, the left anterior descending branch of the coronary artery was ligated. Cardiac ultrasound examination was performed 7 days after surgery. Open the chest and take the heart for HE staining to observe the pathological changes of the heart. Enzyme linked immunosorbent assay(ELISA) for detecting serum interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α), and the levels of superoxide dismutase(SOD) and malondialdehyde(MDA) in myocardium. Protein immunoblotting technology was used for detecting nuclear transcription factor erythroid 2 related factor(Nrf2), heme oxygenase-1(HO-1), and nuclear factor κ B(NF-κ B) expression level in cardiac tissue.Results Cardiac ultrasound examination showed that compared with the MI group, the LVEDd and LVEDs of the MI+ZGR group rats significantly decreased(F/P=45.21/<0.001,95.45/<0.001), while LVEF and LVFS increased(F/P=61.13/<0.001,83.90/<0.001). ELISA detection showed that compared with the MI group, the serum IL-6 and TNF-α levels in the MI+ZGR group of rats were significantly higher Significantly reduced(F/P=237.40/<0.001,532.70/<0.001), myocardial tissue SOD significantly increased(F/P=516.50/<0.001), and MDA significantly decreased(F/P=105.90/<0.001). HE slices showed that ZGR treatment can significantly reduce the infiltration of inflammatory cells and improve the degree of cell swelling in MI rats. Protein immunoblotting technology showed that compared with the MI group, the MI+ZGR group significantly increased the expression levels of Nrf2 and HO-1 proteins in the myocardial tissue of rats(P<0.01), and NF-κB protein level significantly decreased(P<0.01).Conclusion ZGR treatment can protect cardiac function by improving inflammation and oxidative stress levels after MI.

The clinical data of a patient with systemic light chain amyloidosis with proteinuria as the first manifestation were reported and the literature was reviewed.

Clinical data of a patient with TEMPI syndrome were reported and literature review was conducted.

According to the Third International Consensus Definitions for Sepsis and Septic Shock(Sepsis-3),sepsis is defined as “life-threatening organ dysfunction caused by the dysregulated host response to infection”.Although the treatment of sepsis has developed rapidly in the past few years, the incidence rate and mortality of sepsis in clinical treatment are still rising.In addition, due to the various manifestations of sepsis, clinicians still face severe challenges in the diagnosis, treatment and management of sepsis patients.Here, we review the biomarkers that have potential value for early diagnosis of sepsis or assessment of disease severity and prognosis, including 1 Traditional biomarkers related to infection: procalcitonin, C-reactive protein, cytokines, etc; 2 Biomarkers related to inflammation activation and immune imbalance: calprotectin, pentraxin3,soluble CD14 subtype, CD64,monocyte chemoattractant protein-1,adrenomedullin and Pro-Adrenomedullin, soluble triggering receptor expressed on myeloid cell 1,soluble urokinase-type plasminogen activator receptor, toll like receptor 4,programmed death-1 receptor, soluble tumor necrosis factor-1 receptor, etc; 3 New biomarkers related to organ dysfunction: angiopoietin-1 and angiopoietin-2,matrix metalloproteinase, microRNA,Long non-coding RNA,etc.It is hoped that the summary of the above markers will help to optimize the diagnosis and treatment strategies of sepsis and bring help to relevant research.

Epilepsy is one of the most common neurological disorders in children and is characterized by excessive neuronal discharges leading to recurrent, seizure and transient central nervous system malfunctions. Seizures have a tremendous impact on children's growth and development, life and learning, and place a burden on families and society. Most children with epilepsy can have their seizures effectively controlled after regular treatment, but there are still a small number of children who are difficult to control effectively and become refractory to epilepsy. Children with refractory epilepsy tend to have a combination of cognitive impairment. Currently, the treatment of refractory epilepsy in children mainly includes drug therapy, neuromodulation techniques, ketogenic diet therapy and surgery. In this article, we will review the progress in the refractory epilepsy in children.