Correlation between serum CLEC-2，S100A8 / S100A9 levels and major adverse cardio-cerebrovascular events in eld-
erly patients with cardiogenic stroke Li Yuan，Liu Chunping，Zhao Haiyan，Pu Guoming，Liu Sujun，Yang Wei． Depart-
ment of Neurology，Dazhou Central Hospital，Sichuan Province，Dazhou 635000，China
Corresponding author: Yang Wei，E-mail: yw865950@ 163． com
Funding program: Medical Science and Technology Project of Sichuan Health Commission ( 21PJ198)
【Abstract】 Objective To analyze the correlation between serum levels of C-type lectin-like receptor-2 ( CLEC-2) ，
S100A8 / S100A9 and major adverse cardio-cerebrovascular events ( MACCE ) in elderly patients with cardiogenic stroke
( CES) ． Methods One hundred and fiveteen elderly patients with CES admitted to the Department of Neurology，Dazhou
Central Hospital，Sichuan Province from January 2020 to January 2022 were divided into MACCE group and control group
( without MACCE) according to the occurrence of MACCE after discharge． The serum levels of CLEC-2，S100A8 and S100A9
on the day of admission were measured． Multivariate logistic regression was used to analyze the factors affecting the occurrence
of MACCE in elderly patients with CES，and the working characteristic curve ( ＲOC) of subjects was drawn to analyze the val-
ue of serum CLEC-2，S100A8，S100A9 in predicting the occurrence of MACCE in elderly patients with CES． Ｒesults One
of 115 patients lost their visit，28 of the remaining 114 patients had MACCE，and 86 had no MACCE． Among 28 MACE pa-
tients，9 were nonfatal myocardial infarction，7 were heart failure，4 were nonfatal stroke，5 were transient ischemic attack，2
were revascularized，and 1 died． The levels of serum CLEC-2，S100A8，S100A9 water in MACCE group were higher than
those in the control group ( t / P = 9． 898 / ＜ 0． 001，5． 759 / ＜ 0． 001，14． 553 / ＜ 0． 001) ． The results of multivariate logistic
regression analysis showed that atrial fibrillation，high mＲS score at discharge，high CLEC-2，high S100A8，and high S100A9
were risk factors for MACCE in elderly patients with CES ［OＲ ( 95% CI) = 2． 277 ( 1． 334 － 3． 889) ，1． 876 ( 1． 277 － 2．
·872· 疑难病杂志 2023 年 3 月第 22 卷第 3 期 Chin J Diffic and Compl Cas，March 2023，Vol． 22，No． 3

754) ，1． 702 ( 1． 237 － 2． 343) 1． 504 ( 1． 141 － 1． 983) 、1． 484 ( 1． 137 － 1． 978) ］． The area under the curve of serum
CLEC-2，S100A8，S100A9 and their combination to predict MACCE in elderly patients with CES was 0． 705，0． 672，0． 655，
0． 856． The combined prediction efficiency of the three was higher than that of single prediction ( Z / P = 2． 645 /0． 012，3．
178 / ＜ 0． 001，3． 738 / ＜ 0． 001) ． Conclusions The serum CLEC-2，S100A9，S100A8 water levels of elderly CES patients
with MACCE increased on average，which is a risk factor for MACCE，and can be used as a biological indicator for MACCE e-
valuation of elderly CES patients after discharge．
【Key words】 Cardioembolic stroke; Major adverse cardiovascular and cerebrovascular events; C-type lectin-like re-
ceptor-2; Calcium binding protein S100; Elderly