A case of central nervous system lymphoma with cerebellar ataxia as a clinical manifestation and crmp5 antibody positive was reported and a literature review was conducted.

Autoimmune encephalitis is a central nervous system disease associated with anti-neuronal antibodies. Different antibody subtypes usually correspond to different clinical phenotypes, and have great influence on the diagnosis and treatment of the disease. In recent years, with the reported cases of autoimmune encephalitis and the deepening of related studies, it has been found that anti-neuronal antibodies can be superimposed or clinical phenotypes overlap in clinical practice. By collecting the research status at home and abroad, the study reviews the possible mechanism, overlapping types, clinical manifestations and clinical significance of autoimmune encephalitis overlap syndrome.

Chronic airway diseases(CADs) are a class of persistent respiratory diseases that have a serious impact on the quality of life and health status of patients, which are important issues in global public health. Transient receptor potential anchor protein subtype 1(TRPA1) and transient receptor potential vanilloid subtype 1(TRPV1) are ion channel receptors that play a significant role in the pathogenesis of CADS. The activation of TRPV1 and TRPA1 participates in airway smooth muscle contraction, release of inflammatory mediators, and increase in mucus secretion, which can trigger pathological processes such as airway inflammation and hyperresponsiveness. process. Therefore, pharmacological interventions targeting TRPV1 and TRPA1 may become a new strategy for the treatment of CADs. In order to further summaries the research progress of TRPV1, TRPA1 and CADs, this paper reviews the pathogenesis and clinical application of TRPV1 and TRPA1, with a view to providing a reference for the diagnosis and treatment of CADs.

Cystinosis is a rare autosomal recessive inherited disease. The mutation of cystine transporter gene of CTNS causes cystine accumulation in the lysosomes of the kidney and other organs, leading to organ dysfunction. Although the genetic background is clear, cystine accumulation is not the only mechanism of organ damage. At present, thiamine as a traditional treatment regimen, although it can partially prevent the progression of organ damage by depleting cystine, its effect is insufficient to the damage already caused, because they are often irreversible. In the past, it was thought that the prognosis of the disease was very poor, but recently a variety of large studies at home and abroad have shown that early intervention can significantly improve the prognosis of patients, so early diagnosis of the disease is particularly important. More attention is needed to improve the understanding of the disease, to address organ damage from non-accumulative mechanisms, and to develop new treatments to improve the quality of life of patients. The purpose of this review is to sort out the recent advances in the pathogenesis, The latest advances in treatment and monitoring methods are expected to provide patients with earlier diagnosis and better treatment options, thereby delaying disease progression, prolonging patients' survival and improving their quality of life.

Duchenne muscular dystrophy(DMD) is characterized by symmetrical limb weakness, which is a hereditary muscle degenerative disease and belongs to the category of "flaccidity syndrome" in traditional Chinese medicine. According to the theory of zang-fu syndrome differentiation, the muscles, tendons and bones of the limbs are dominated by the spleen, liver and kidney, so the weakness of the muscles, tendons and bones is closely related to the deficiency of the spleen, liver and kidney. However, Duchenne muscular dystrophy has various symptoms, progressive development and complex pathogenesis, and although there is severe muscle weakness in the early stage of the disease, there is no typical symptom of viscera involvement, so it is difficult to analyze its clinical characteristics and morbidity mechanism by viscera deficiency. Based on the theory of extra meridians and collateral disease, this paper discusses the mechanism of morbidity in traditional Chinese medicine(TCM) of Duchenne muscular dystrophy(DMD), and proposes that congenital deficiency is the root of morbidity, the deficiency of extra meridians is the mechanism of symptom initiation, the lesion of collaterals is the factor of disease progression, and the accumulation of collaterals is the key to cardiopulmonary failure in the late stage of the disease.