Objective To analyze the relationship between cerebral iron deposition and cerebral hemorrhage in patients with cerebral vascular malformation after embolization, so as to provide reference for clinical diagnosis, treatment and prognosis evaluation.Methods From June 2020 to June 2022, 77 patients with cerebral arteriovenous malformations admitted to the Neurosurgery Department of Beijing Pinggu District Hospital and the Neurovascular Department of Beijing Tiantan Hospital were collected as the study subjects. All patients were treated with intravascular embolization. According to the head CT results within 7 days after embolization, they were divided into 65 patients in the non-cerebral hemorrhage group and 12 patients in the cerebral hemorrhage group. Compare the clinical data of the two groups, cerebral iron deposition(magnetic susceptibility) before embolization. Observe the changes of brain hematoma volume and brain iron deposition in patients with intracerebral hemorrhage on the 1st, 3rd and 7th day of hemorrhage. The relationship between cerebral iron deposition and clinical data in patients with cerebral vascular malformation was analyzed by point binary correlation, and the value of cerebral iron deposition in predicting cerebral hemorrhage after embolization in patients with cerebral vascular malformation was evaluated by drawing the working characteristic curve(ROC) of subjects.Results Within 7 days after embolization, 12 cases(15.58%) of intracranial hemorrhage were confirmed by CT examination. The proportion of drainage vein embolism in cerebral hemorrhage group was higher than that in non-cerebral hemorrhage group(χ²/P=4.663/0.031). The magnetic susceptibility values of thalamus, putamen, hippocampus, red nucleus and substantia nigra in patients with intracerebral hemorrhage before embolization were higher than those in patients without intracerebral hemorrhage(t/P=4.340/0.001, 2.944/0.004, 4.833/<0.001, .="" there="" was="" no="" significant="" difference="" in="" the="" magnetic="" susceptibility="" values="" of="" caudate="" nucleus="" and="" globus="" pallidus="" between="" two="" groups="" before="" p="">0.05). Through point binary correlation analysis, gender was related to cerebral iron deposition in thalamus(r=0.293, P=0.010), while other baseline data were not related to cerebral iron deposition(P>0.05). ROC curve analysis showed that the area under the curve(AUC) of thalamus, putamen, hippocampus, red nucleus, substantia nigra and their combined magnetic susceptibility values for predicting cerebral hemorrhage after embolization in patients with vascular malformation were 0.845, 0.741, 0.850, 0.706, 0.750, and 0.979, respectively, and the combined prediction efficiency of the five was higher than that of the thalamus, putamen, red nucleus and substantia nigra alone(Z/P=2.129/0.033, 2.560/0.010, 3.243/0.001, 2.490/0.013). On the 1st, 3rd and 7th day of cerebral hemorrhage after embolization, the change trend of cerebral iron deposition was consistent with the volume value of cerebral hematoma.Conclusion Cerebral iron deposition is related to cerebral hemorrhage after embolization in patients with cerebral vascular malformation. Excessive cerebral iron deposition can increase the risk of cerebral hemorrhage, and cerebral iron deposition may be related to the severity of cerebral hemorrhage in patients.

Cerebrovascular malformation;                    Brain iron deposition;                    Intravascular embolization;                    Cerebral hemorrhage;                    Correlation;