Objective To analyze the predictive effect of serum hepatocyte growth factor(HGF) and interleukin(IL)-10 on adverse pregnancy outcome of gestational diabetes mellitus(GDM). Methods One hundred and twenty GDM patients admitted to the Department of Obstetrics and Gynaecology of the Sixth Affiliated Hospital of Xinjiang Medical University from April 2019 to April 2021 were selected as the research objects, and were divided into good outcome group and bad outcome group according to the pregnancy outcome during the follow-up period. Before treatment, the serum HGF, IL-10 levels and other laboratory indicators [fasting blood glucose(FPG), postprandial blood glucose(2hPG), glycosylated hemoglobin(HbA_1c), progesterone(P), estradiol(E₂), luteinizing hormone(LH)] of the two groups were detected and compared. Logistic regression analysis was used to analyze the influencing factors of adverse pregnancy outcome in GDM patients; The predictive efficacy of serum HGF and IL-10 on adverse pregnancy outcomes in GDM patients was analyzed by the receiver operating characteristic curve(ROC). Draw decision curve to analyze the net benefit rate of serum HGF and IL-10 in predicting adverse pregnancy outcome of GDM patients. Results Among 120 patients with GDM, 112 completed follow-up and 8 lost follow-up. Among them, adverse pregnancy outcome accounted for 25.89%(29/112) and good pregnancy outcome accounted for 74.11%(83/112). The gestational weeks of the patients in the adverse outcome group were less than those in the good outcome group(t/P=28.634/<0.001). The whole blood FPG, HbA_1c and serum E₂ levels in patients with adverse outcome were higher than those in patients with good outcome, and the serum HGF and IL-10 levels were lower than those in patients with good outcome(t/P=2.030/0.045, 2.284/0.027, 2.598/0.011, 5.206/< 0.001, 5.667/<0.001). Logistic regression analysis showed that high expression of HGF and IL-10 in serum was a protective factor for adverse pregnancy outcomes in GDM patients [OR(95% CI)=0.013(0.001-0.190), 0.599(0.460-0.780)]. The ROC curve results showed that the area under the curve(AUC) of serum HGF, IL-10 and their combination in predicting adverse pregnancy outcomes in GDM patients were 0.786, 0.798 and 0.824, respectively, but there was no significant difference between their combined prediction efficiency and single index(Z/P=0.568/0.570, 0.389/0.697). The decision curve showed that the net benefit rate of serum HGF and IL-10 in predicting adverse pregnancy outcome of GDM patients was higher than that of single indicator detection. Conclusion The low expression of HGF and IL-10 in serum can increase the risk of adverse pregnancy outcome in GDM patients, and both of them can be used as predictors of pregnancy outcome in GDM patients.

Gestational diabetes mellitus;                    Pregnancy outcome;                    Hepatocyte growth factor;                    Interleukin-10;