Objective To analyze the expression of serum platelet reactive protein 1(TSP-1) and pentameric protein 3(PTX-3) in patients with hypertensive disorder complicating pregnancy(HDP), and to establish a risk model for predicting adverse pregnancy outcomes. Methods One hundred and forty eight cases of HDP patients diagnosed and treated in the Obstetrics Department of the Second Affiliated Hospital of Hainan Medical College from January 2020 to March 2022 were selected as the observation group, and were divided into 109 cases with good pregnancy outcomes and 39 cases with bad pregnancy outcomes according to pregnancy outcomes. 148 healthy pregnant women were selected as control group. The levels of serum TSP-1, PTX-3 and the incidence of adverse pregnancy outcomes were compared between the two groups. Logistic regression was used to analyze the influencing factors of adverse pregnancy outcome in HDP, and a risk model was constructed. Draw the ROC to analyze the value of serum TSP-1 and PTX-3 in evaluating the adverse pregnancy outcome of HDP patients. Results The levels of serum TSP-1 and PTX-3 in the observation group were higher than those in the control group(t/P=6.146/<0.001, 24.532/<0.001). The levels of serum TSP-1 and PTX-3 in the subgroup with poor pregnancy outcome were higher than those in the subgroup with good pregnancy outcome(t/P=6.224/<0.001, 3.360/0.001). The incidence of premature delivery, fetal distress and total adverse pregnancy outcome in the observation group was higher than that in the control group(χ²/P=11.594/<0.001,7.498/0.006,24.306/<0.001). Logistic regression analysis showed that the increase of serum TSP-1 and PTX-3 was a risk factor for adverse pregnancy outcomes in HDP patients [OR(95%CI)=3.493(1.864-6.544), 3.030(1.607-5.712)]. Establish logistic regression model: logit(P)=-6.384+1.251×TSP-1+1.108×PTX-3, according to the Hosmer-Lemeshow goodness of fit test, the goodness of fit is good. ROC curve analysis showed that AUC value of adverse pregnancy outcome assessed by risk model based on serum TSP-1 and PTX-3 was greater than single prediction(Z/P=2.756/0.005, 2.741/0.004). Conclusion The serum TSP-1 and PTX-3 were highly expressed in HDP patients. The risk model of adverse pregnancy outcome based on the expression of serum TSP-1 and PTX-3 can effectively evaluate the adverse pregnancy outcome of HDP patients.

Hypertensive disorders of pregnancy;                    Thrombospondin 1;                    Pentraxin-3;                    Pregnancy outcomes;