Ｅｆｆｅｃｔ ｏｆ ｋｅｔｏｇｅｎｉｃ ｄｉｅｔ ｃｏｍｂｉｎｅｄ ｗｉｔｈ ｈｉｇｈ⁃ｉｎｔｅｎｓｉｔｙ ｉｎｔｅｒｍｉｔｔｅｎｔ ｔｒａｉｎｉｎｇ ｏｎ ｎｏｎａｌｃｏｈｏｌｉｃ ｆａｔｔｙ ｌｉｖｅｒ Ｗｅｎ Ｙｉｆｅｉ，Ｚｈｅｎｇ Ｒｏｎｇｊｉｏｎｇ， Ｌｉｕ Ｈｕａｙｉｎｇ， Ｐａｎ Ｋｅｊｕｎ． Ｉｎｆｅｃｔｉｏｕｓ ＤｉｓｅａｓｅｓＬｉｖｅｒ Ｄｉｓｅａｓｅ Ｃｅｎｔｅｒ ｏｆ ｔｈｅ Ｆｉｒｓｔ Ａｆｆｉｌｉａｔｅｄ Ｈｏｓｐｉｔａｌ ｏｆ Ｘｉｎｊｉａｎｇ
Ｍｅｄｉｃａｌ Ｕｎｉｖｅｒｓｉｔｙ， Ｘｉｎｊｉａｎｇ Ｐｒｏｖｉｎｃｅ，Ｕｒｕｍｑｉ ８３００５４，Ｃｈｉｎａ
Ｃｏｒｒｅｓｐｏｎｄｉｎｇ ａｕｔｈｏｒ： Ｐａｎ Ｋｅｊｕｎ， Ｅ⁃ｍａｉｌ： １５８９９１９９１５１＠ １６３． ｃｏｍＦｕｎｄｉｎｇ ｐｒｏｇｒａｍ： Ｎａｔｕｒａｌ Ｓｃｉｅｎｃｅ Ｆｕｎｄ ｏｆ Ｘｉｎｊｉａｎｇ Ｕｙｇｕｒ Ａｕｔｏｎｏｍｏｕｓ Ｒｅｇｉｏｎ （２０２０Ｄ０１Ｃ４２１）
【 Ａｂｓｔｒａｃｔ】 Ｏｂｊｅｃｔｉｖｅ To observe the effect of ketogenic diet (KD) combined with high intensity interval training
(HIIT) on nonalcoholic fatty liver (NAFL). Ｍｅｔｈｏｄｓ From June 2020 to March 2022, 112 patients with NAFL admitted to
the Infectious Disease/Liver Disease Center of the First Affiliated Hospital of Xinjiang Medical University were selected as
the study subjects. They were divided into the control group and the observation group with a ratio of 1:1 according to the
random number table, with 56 patients in each group. The control group was treated with HIIT intervention, and the obser⁃
vation group was treated with KD intervention on the basis of the control group. Obesity indexes (body mass index (BMI),
waist to hip ratio (WHR), obesity degree, body fat rate (Fat)), glucose metabolism indexes ［ fasting insulin (FINS), fasting
blood glucose (FPG), insulin resistance index (HOMA⁃IR)］ , lipid metabolism indexes (TG), low density lipoprotein cholesterol
(LDL⁃C), high density lipoprotein cholesterol (HDL⁃C) Inflammatory factors ［ high sensitivity C⁃reactive protein (hs⁃CRP), in⁃
terleukin⁃6 (IL⁃6), IL⁃8］ , sterol regulatory element binding protein⁃1 (SREBP⁃1c), retinol binding protein⁃4 (RBP4), muscle
mass , bone mass level. Ｒｅｓｕｌｔｓ After 3 months of intervention, BMI, WHR, obesity and Fat in the observation group were
lower than those in the control group (
t/P = 6.183/ < 0.001, 4.224/ < 0.001, 3.362/0.001, 3.268/0.001), FINS, FPG, HOMA⁃IR lev⁃
els were lower than those in the control group (
t/P = 2.888/0.005, 2.983/0.004, 2.459/0.016), TG, LDL⁃C levels were lower thanthose in the control group, HDL⁃C levels were higher than those in the control group (

t/P = 3.582/ < 0.001, 3.416/ < 0.001,4.036/ < 0.001), The level of serum hs⁃CRP, IL⁃6 ,IL⁃8 was lower than that of the control group (
t/P = 3.109/0.002, 3.862/ <
0.001, 3.431/ < 0.001), and the level of SREBP⁃1c and RBP4 in serum was lower than that of the control group (
t/P = 5.248/ <
0.001, 3.978/0.002). The muscle mass was higher than that of the control group (
t/P = 2.613/0.010). There was no significant
difference in bone mass between the two groups before and after the intervention (
P > 0.05). Ｃｏｎｃｌｕｓｉｏｎ The intervention
effect of KD and HIIT on NAFL is better, which can effectively control obesity, reduce body mass, and regulate glycolipid
metabolism, inflammatory factors and serum SREBP⁃1c, RBP4 levels, without affecting muscle mass and bone mass.
【 Ｋｅｙ ｗｏｒｄｓ】 Non⁃alcoholic fatty liver disease; Ketogenic diet; High⁃intensity interval training; Glucose and lipid me⁃
tabolism; Inflammatory factors