The effects of Jinlida Granules combined with Liraglutide in the treatment of T2DM on patient efficacy,pancreatic function,and oxidative stress levels

Abstract:Objective To investigate the effect of Jinlida Granules combined with liraglutide in the treatment of newly diagnosed type 2 diabetes mellitus(T2DM) and its influence on islet function and oxidative stress level.Methods From January 2020 to December 2023, 120 newly diagnosed T2DM patients in the Department of endocrinology of Xingtai Central Hospital were selected, and they received conventional medication, diet and exercise therapy in the hospital. According to the random number table method, they were divided into control group and study group, with 60 cases in each group. The control group was treated with liraglutide, and the study group was treated with Jinlida Granules Combined with liraglutide. Both groups were treated for 12 weeks. The curative effects of two groups of T2DM patients were compared, and the changes of blood glucose indexes[fasting blood glucose(FBG), 2-hour postprandial blood glucose(2-hour PBG), glycosylated hemoglobin(HbA_1c)], islet function[islet β cell function index(HOMA-β), insulin sensitivity index(homa-is), insulin resistance index(HOMA-IR)]and oxidative stress [malondialdehyde(MDA), superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px)] levels and adverse reactions were analyzed.Results The total effective rate of the study group was better than that of the control group [91.67% vs 78.33%, χ²=4.183, P=0.041]. After 12 weeks of treatment, FBG, 2h FBG and HbA_1c in the two groups were lower than before treatment, and the study group was lower than the control group( t/P=4.372/<0.001, 2.646/0.009, 4.540/<0.001). After 12 weeks of treatment, the levels of HOMA-β and homa-is in the two groups were higher than those before treatment, and HOMA-IR in the study group was lower than that in the control group( t/P=25.323/<0.001, 2.387/0.019, 2.419/0.017).After 8 and 12 weeks of treatment, SOD and GSH-Px in the two groups were higher than those before treatment and after 4 weeks of treatment, and MDA in the study group was lower than that in the control group( t/P=3.719/<0.001, 3.347/0.001, 2.305/0.023 at 8 weeks of treatment; t/P=8.701/<0.001, 5.309/<0.001, 8.461/<0.001 12="" at="" weeks="" of="" .="" during="" the="" 12-week="" treatment="" different="" types="" adverse="" reactions="" occurred="" in="" both="" groups.="" there="" was="" no="" significant="" difference="" total="" incidence="" between="" study="" group="" and="" control="" p="">0.05).Conclusion The combination of traditional Chinese and Western medicine and the use of Jinlida granules combined with Liraglutide can improve the clinical efficacy of T2DM patients, improve pancreatic function, and reduce oxidative stress levels.