Objective To analyze The relationship between preoperative serum soluble hemoglobin scavenger receptor(sCD163) and soluble tumor necrosis factor-like weak inducer of apoptosis(sTWEAK) and prognosis of patients with Stanford type A aortic dissection. Methods From January 2016 to March 2019, 143 patients with Stanford type A aortic dissecting aneurysm admitted to the Department of Cardiac Surgery of the Fourth Hospital of Hebei Medical University were selected as the observation group. According to the 3-year follow-up results, the patients were divided into 115 survival subgroups. 28 patients died in the subgroup; another 140 healthy people who underwent physical examination in the hospital during the same period were selected as the healthy control group. Comparison of serum sCD163 and sTWEAK levels in each group; Pearson analysis of the correlation between preoperative serum sCD163 and sTWEAK levels in patients with Stanford type A aortic dissection; Logistic regression analysis of the risk factors for death in patients with Stanford type A aortic dissection; The predictive value of preoperative serum sCD163 and sTWEAK in patients with Stanford type A aortic dissecting aneurysm was analyzed by the operator operating characteristic curve(ROC).Results The proportion of hypertension, preoperative serum low-density lipoprotein cholesterol(LDL-C), cardiac troponin I(cTnI), and D-dimer levels in the death subgroup were significantly higher than those in the survival subgroup [χ2(t)/P=4.481/0.034, 2.441/0.016, 2.181/0.031, 7.571/<0.001]; the preoperative serum sCD163 and sTWEAK levels in the observation group were significantly higher than those in the healthy control group(t/P=33.220/<0.001, 25.643/<0.001); The preoperative serum sCD163 and sTWEAK levels in the group were significantly higher than those in survival subgroup(t/P=7.871/<0.001, 8.097/<0.001); preoperative serum sCD163 and sTWEAK levels in patients with Stanford type A aortic dissection were positively correlated(r=0.449,P<0.001); preoperative LDL C, D dimer, sCD163, and sTWEAK levels were the risk factors for death in patients with Stanford type A aortic dissection [OR(95%CI)=3.066(2.125-4.423), 2.090(1.215-3.596), 2.396(1.381-4.156), 2.979(2.183-4.064)]; preoperative serum sCD163, sTWEAK and their combination predict the death of patients with Stanford type A aortic dissection under the curve The areas were 0.860, 0.887, and 0.935, respectively. The combined prediction efficiency of the two was higher than the single prediction(Z/P=1.901/0.028, 2.331/0.019). Conclusion Preoperative serum sCD163 and sTWEAK levels in patients with Stanford type A aortic dissecting aneurysm are elevated, which are risk factors for death and have certain predictive value for death.

“没有全民健康，就没有全面小康”。党的十八大以来，以习近平同志为核心的党中央，坚持以人民为中心的发展思想，把人民健康放在优先发展的战略位置。研究表明，脑卒中是我国居民死亡的首要原因，也是成年人致残的主要原因([1-3])，其严重威胁着我国人民健康。为应对这一严峻的形势，国家卫生健康委员会和中国卒中中心联盟结合我国医疗实际情况，积极组织并开展具有中国特色的卒中中心建设工作。