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《YiNanBing ZaZhi》2023 Vol.22,No.2
  • Relationship between serum FGF5 , TF levels and adverse pregnancy outcome in pre-eclampsia pregnant women
    Author:CuZhangxia, Zhang Na keyword:Preeclampsia; Fibroblast growth factor 5; Tissue factor; Adverse pregnancy outcomes; Correlation;
    Objective To explore the correlation between the levels of serum fibroblast growth factor 5(FGF5), tissue factor(TF) and adverse pregnancy outcome in pre-eclampsia pregnant women. Methods Seventy-two pregnant women with preeclampsia who were examined and delivered in the Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine from January 2017 to March 2022 were selected as the observation group. According to the severity of the patient's condition, they were divided into mild subgroup of 40 cases and severe subgroup of 32 cases. According to the pregnancy outcome of preeclampsia patients, they were divided into poor pregnancy outcome subgroup of 22 cases and good pregnancy outcome subgroup of 50 cases. In addition, 78 singleton pregnant women with healthy obstetrics in the same period were selected as the healthy control group. The expression level of serum FGF5 was detected by real-time quantitative PCR, the level of serum TF was determined by enzyme-linked immunosorbent assay, and the level of activated partial prothrombin time(APTT), fibrinogen(FIB), prothrombin time(PT), and platelet(PLT) in plasma were detected by automatic hemagglutination instrument. Pearson method was used to analyze the correlation between serum FGF5, TF and plasma coagulation index in patients with preeclampsia. Logistic regression analysis was used to analyze the independent risk factors affecting the adverse pregnancy outcome of pre-eclampsia pregnant women. Results Compared with the healthy control group, the expression level of serum FGF5 and TF in the observation group increased(t/P=19.916/<0.001, 14.530/<0.001). Compared with mild subgroup, the expression level of serum FGF5 and TF in severe subgroup increased(t/P=5.624/<0.001, 6.938/<0.001). Compared with the subgroup with good pregnancy outcome, the levels of APTT, PT and PLT in the subgroup with poor pregnancy outcome decreased(t/P=12.202/<0.001, 4.294/<0.001, 78.325/<0.001), and the expression levels of FIB, FGF5 and TF increased(t/P=6.436/<0.001, 10.600/<0.001, 12.562/<0.001). Pearson analysis showed that serum FGF5 and TF were negatively correlated with APTT, PT and PLT(FGF5:r=-0.386,-0.416,-0.463; TF:r=-0.394,-0.434,-0.459,P<0.001), and positively correlated with FIB(r=0.447, 0.428, P<0.001). Logistic regression analysis showed that high FGF5, high TF, high FIB and low PLT were independent risk factors for adverse pregnancy outcome in pre-eclampsia pregnant women [OR(95% CI)=2.432(1.577-3.750), 2.203(1.494-3.248), 1.957(1.169-3.277), 2.018(1.327-3.069),P<0.05].Conclusion The expression level of serum FGF5 and TF in pre-eclampsia pregnant women was significantly increased, which was an independent risk factor for adverse pregnancy outcome in pre-eclampsia pregnant women.
  • Relationshi between serum IL-6. TNF-A,IGF- levels and blood lipids, thyroid function and pregnancy outcome inpatients with subclinical hypothyroidism during pregnancy
    Author:Shen Juanjuan, Haliya Halimubieke, Wang Denglan, Cauein , Mukedasi Aihemaiti keyword:Subclinical hypothyroidism,pregnancy; Interleukin-6; Tumor necrosis factor-α; Insulin-like growth factor-1; Blood lipid; Thyroid function; Pregnancy outcomes; Correlation;
    Objective To investigate the serum interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) in patients with subclinical hypothyroidism(SCH) during pregnancy. The relationship between the expression of insulin-like growth factor-1(IGF-1) and blood lipid, thyroid function and pregnancy outcome. Methods From March 2018 to September 2020, 52 patients with SCH were selected as the observation group in the Obstetrics Department of the Second Affiliated Hospital of Xinjiang Medical University, and were divided into 42 normal pregnancy subgroups and 10 poor pregnancy subgroups according to the pregnancy outcome. In addition, 35 non-SCH pregnant women in the same period were selected as the control group. Observe and compare the serum IL-6 and TNF-α of pregnant women in each group, IGF-1 level and blood lipid [total cholesterol(TC), triacylglycerol(TG), low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol(HDL-C)], fasting blood glucose(FPG), renal function [blood urea nitrogen(BUN), creatinine(SCR), uric acid(UA)] and thyroid function indicators [thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free thyroid hormone(FT4)]. Analysis of serum IL-6 and TNF-α in pregnant women with SCH, the relationship between IGF-1 level and blood lipid, thyroid function.Results Compared with the control group, the serum IL-6 and TNF-α of pregnant women in the observation group, the levels of TC, TG, LDL-C and TSH increased significantly(t/P=4.697/<0.001, 5.815/< 0.001, 2.311/0.023, 2.214/0.030, 3.168/0.002, 2.245/0.027), while the levels of IGF-1 decreased significantly(t/P=2.959/0.004); There was no significant difference in HDL-C, FPG, BUN, SCR, UA, FT4 and FT3 between the two groups(P>0.05). Serum IL-6 and TNF-α of pregnant women in poor pregnancy subgroup The level of IGF-1 was significantly higher than that of normal pregnancy subgroup(t/P=2.706/0.009, 2.105/0.040), while the level of IGF-1 was significantly lower than that of normal pregnancy subgroup(t/P=2.335/0.024). Pearson correlation analysis showed that serum IL-6 and TNF-α were positively correlated with TC, TG, LDL-C, HDL-C, TSH, FT4, FT3 levels, while IGF-1 was negatively correlated with TSH(P<0.05). Conclusion The level of serum IL-6 and TNF-α in patients with SCH increased and the level of IGF-1 decreased, which was related to blood lipid, thyroid function and adverse pregnancy outcome.
  • Predictive value of serum HGF and IL-10 in pregnant women with diabetes mellitus on adverse pregnancy outcomes
    Author:lu Xia , He Xiaoli, Maynuerguli Rexiti, Ding xuewei, Li Junlin keyword:Gestational diabetes mellitus; Pregnancy outcome; Hepatocyte growth factor; Interleukin-10;
    Objective To analyze the predictive effect of serum hepatocyte growth factor(HGF) and interleukin(IL)-10 on adverse pregnancy outcome of gestational diabetes mellitus(GDM). Methods One hundred and twenty GDM patients admitted to the Department of Obstetrics and Gynaecology of the Sixth Affiliated Hospital of Xinjiang Medical University from April 2019 to April 2021 were selected as the research objects, and were divided into good outcome group and bad outcome group according to the pregnancy outcome during the follow-up period. Before treatment, the serum HGF, IL-10 levels and other laboratory indicators [fasting blood glucose(FPG), postprandial blood glucose(2hPG), glycosylated hemoglobin(HbA1c), progesterone(P), estradiol(E2), luteinizing hormone(LH)] of the two groups were detected and compared. Logistic regression analysis was used to analyze the influencing factors of adverse pregnancy outcome in GDM patients; The predictive efficacy of serum HGF and IL-10 on adverse pregnancy outcomes in GDM patients was analyzed by the receiver operating characteristic curve(ROC). Draw decision curve to analyze the net benefit rate of serum HGF and IL-10 in predicting adverse pregnancy outcome of GDM patients. Results Among 120 patients with GDM, 112 completed follow-up and 8 lost follow-up. Among them, adverse pregnancy outcome accounted for 25.89%(29/112) and good pregnancy outcome accounted for 74.11%(83/112). The gestational weeks of the patients in the adverse outcome group were less than those in the good outcome group(t/P=28.634/<0.001). The whole blood FPG, HbA1c and serum E2 levels in patients with adverse outcome were higher than those in patients with good outcome, and the serum HGF and IL-10 levels were lower than those in patients with good outcome(t/P=2.030/0.045, 2.284/0.027, 2.598/0.011, 5.206/< 0.001, 5.667/<0.001). Logistic regression analysis showed that high expression of HGF and IL-10 in serum was a protective factor for adverse pregnancy outcomes in GDM patients [OR(95% CI)=0.013(0.001-0.190), 0.599(0.460-0.780)]. The ROC curve results showed that the area under the curve(AUC) of serum HGF, IL-10 and their combination in predicting adverse pregnancy outcomes in GDM patients were 0.786, 0.798 and 0.824, respectively, but there was no significant difference between their combined prediction efficiency and single index(Z/P=0.568/0.570, 0.389/0.697). The decision curve showed that the net benefit rate of serum HGF and IL-10 in predicting adverse pregnancy outcome of GDM patients was higher than that of single indicator detection. Conclusion The low expression of HGF and IL-10 in serum can increase the risk of adverse pregnancy outcome in GDM patients, and both of them can be used as predictors of pregnancy outcome in GDM patients.
  • Relationship between cerebral iron deposition and cerebral hemorrhage after embolization in patients with cerebravascular malformation
    Author:Zhang Yunpeng" , Chen Xiaoshua, Wang Yan , Li Yuming, li Changbao , li Hao. keyword:Cerebrovascular malformation; Brain iron deposition; Intravascular embolization; Cerebral hemorrhage; Correlation;
    Objective To analyze the relationship between cerebral iron deposition and cerebral hemorrhage in patients with cerebral vascular malformation after embolization, so as to provide reference for clinical diagnosis, treatment and prognosis evaluation.Methods From June 2020 to June 2022, 77 patients with cerebral arteriovenous malformations admitted to the Neurosurgery Department of Beijing Pinggu District Hospital and the Neurovascular Department of Beijing Tiantan Hospital were collected as the study subjects. All patients were treated with intravascular embolization. According to the head CT results within 7 days after embolization, they were divided into 65 patients in the non-cerebral hemorrhage group and 12 patients in the cerebral hemorrhage group. Compare the clinical data of the two groups, cerebral iron deposition(magnetic susceptibility) before embolization. Observe the changes of brain hematoma volume and brain iron deposition in patients with intracerebral hemorrhage on the 1st, 3rd and 7th day of hemorrhage. The relationship between cerebral iron deposition and clinical data in patients with cerebral vascular malformation was analyzed by point binary correlation, and the value of cerebral iron deposition in predicting cerebral hemorrhage after embolization in patients with cerebral vascular malformation was evaluated by drawing the working characteristic curve(ROC) of subjects.Results Within 7 days after embolization, 12 cases(15.58%) of intracranial hemorrhage were confirmed by CT examination. The proportion of drainage vein embolism in cerebral hemorrhage group was higher than that in non-cerebral hemorrhage group(χ2/P=4.663/0.031). The magnetic susceptibility values of thalamus, putamen, hippocampus, red nucleus and substantia nigra in patients with intracerebral hemorrhage before embolization were higher than those in patients without intracerebral hemorrhage(t/P=4.340/0.001, 2.944/0.004, 4.833/<0.001, .="" there="" was="" no="" significant="" difference="" in="" the="" magnetic="" susceptibility="" values="" of="" caudate="" nucleus="" and="" globus="" pallidus="" between="" two="" groups="" before="" p="">0.05). Through point binary correlation analysis, gender was related to cerebral iron deposition in thalamus(r=0.293, P=0.010), while other baseline data were not related to cerebral iron deposition(P>0.05). ROC curve analysis showed that the area under the curve(AUC) of thalamus, putamen, hippocampus, red nucleus, substantia nigra and their combined magnetic susceptibility values for predicting cerebral hemorrhage after embolization in patients with vascular malformation were 0.845, 0.741, 0.850, 0.706, 0.750, and 0.979, respectively, and the combined prediction efficiency of the five was higher than that of the thalamus, putamen, red nucleus and substantia nigra alone(Z/P=2.129/0.033, 2.560/0.010, 3.243/0.001, 2.490/0.013). On the 1st, 3rd and 7th day of cerebral hemorrhage after embolization, the change trend of cerebral iron deposition was consistent with the volume value of cerebral hematoma.Conclusion Cerebral iron deposition is related to cerebral hemorrhage after embolization in patients with cerebral vascular malformation. Excessive cerebral iron deposition can increase the risk of cerebral hemorrhage, and cerebral iron deposition may be related to the severity of cerebral hemorrhage in patients.
  • Arthroscopic osteophyte grinding combined with suture absorbable anchor screw repair for treatment of femoral acetabular impaction with glenoid lip injury
    Author:Zhang Wei, Chen Hong , Peng Chao, Zhang Xihu keyword:Femoroacetabular impingement; Glenoid labral injury; Bone grinding; Wire-wound absorbable anchors; Arthroscopy; Traumatic stress; Hip joint function;
    Objective To observe the efficacy and safety of arthroscopic osteophyte grinding combined with suture absorbable anchor screw repair in the treatment of femoral acetabular impaction with glenoid lip injury. Methods Seventy patients with femoral acetabulum impaction and glenoid lip injury were selected from the joint sports medical ward of Hengshui People's Hospital of Hebei Province from February 2018 to February 2020. They were divided into control group and observation group according to the method of random number table, with 35 patients in each group. The control group was treated with arthroscopic osteophyte grinding and glenoplasty, while the observation group was treated with arthroscopic osteophyte grinding and suture absorbable anchor nail repair. The occurrence of surgery and complications, trauma stress index [cortisol(Cor), adrenocorticotropic hormone(ACTH), C-reactive protein(CRP)], hip joint function(modified Harris score), pain degree(VAS score), hip joint range of motion before and after surgery were compared between the two groups, as well as patients' satisfaction with curative effect. Results The operation time in the observation group was longer than that in the control group(t/P=3.594/0.001). The levels of serum Cor, ACTH and CRP in the two groups increased first and then decreased on the 1st, 3rd and 7th day after operation(P<0.01), and the levels of serum Cor, ACTH and CRP in the observation group were lower than those in the control group on the 1st, 3rd and 7th day after operation(P<0.01). The modified Harris score of the two groups showed an upward trend at 3 months, 6 months, 1 year and 2 years after operation, while the VAS score showed a downward trend(P<0.01), and the improvement degree of the observation group was significantly better than that of the control group(P<0.001). The flexion, pronation and abduction of the hip joint in the two groups showed an increasing trend at 3 months, 6 months, 1 year and 2 years after operation(P<0.01), and the increase in the observation group was higher than that in the control group(P<0.001). The satisfaction degree of patients in the observation group was higher than that in the control group(χ2/P=4.861/0.028). The incidence of complications in the observation group was slightly lower than that in the control group, but the difference was not statistically significant(χ2/P=1.790/0.181). Conclusion Arthroscopic osteophyte grinding combined with suture absorbable anchor nail repair can promote the recovery of hip joint function, reduce pain, improve traumatic stress response, reduce the incidence of complications, and improve patient satisfaction with treatment.