Ｒelationship between serum albumin γ-glutamyltransferase level and hyperuricemia in adult idiopathic membranous
nephropathy Guo Shanshan，Xu Yang，Guo Li，Li Jiandong，Zheng Xijie，Chen Hang． Department of Nephrology，Affilia-
ted Hospital of Hebei University ，Hebei Province，Baoding 071000，China
Corresponding author: Guo Li，E-mail: guoli1983@ sina． com
Funding program: Baoding Science and Technology Bureau Project ( 2041ZF316)
【Abstract】 Objective To analyze serum albumin γ-Glutamyltransferase ( γ-GTP) ． The relationship between GTP
level and hyperuricemia ( HUA) in adult idiopathic membranous nephropathy ( IMN) ． Methods One hundred and thirty-six
patients with IMN admitted to the Department of Nephrology of the Affiliated Hospital of Hebei University from January 2020 to
December 2021 were selected，and the patients were divided into 36 patients in the HUA group and 100 patients in the non-
HUA group according to whether they had HUA． Collect relevant clinical data and detect serum albumin γ-GTP level，Pearson
method for analysis of serum albumin γ-Correlation between GTP level and uric acid ( UA) level，multi-factor logistic regres-
sion analysis of risk factors for the occurrence of UA in IMN patients，and the analysis of serum albumin γ-The value of GTP in
diagnosis of HUA in patients with IMN． Ｒesults Serum albumin in HUA group is lower than that in non-HUA group γ-The lev-
el of GTP was higher than that of non-HUA group ( t / P = 6． 591 / ＜ 0． 001，10． 147 / ＜ 0． 001) ． Pearson correlation analysis
showed that there was a negative correlation between serum albumin and UA level in HUA group ( r / P = － 0． 737 / ＜ 0． 001) ，γ-
GTP level was positively correlated with UA level ( r / P = 0． 774 / ＜ 0． 001) ． Multivariate logistic regression analysis showed that
high serum creatinine，hypertension γ-High GTP is a risk factor for the occurrence of UA in IMN patients ［OＲ ( 95% CI) = 2．
064 ( 1． 136 － 3． 754) ，1． 514 ( 1． 087 － 2． 109) ，1． 349 ( 1． 102 － 1． 650) ］，and high serum albumin is a protective factor ［OＲ
( 95% CI) = 0． 674 ( 0． 481 － 0． 944) ］． ＲOC curve analysis showed that serum albumin γ-The area under the curve of HUA in
IMN patients diagnosed by GTP and their combination was 0． 785，0． 768 and 0． 908，and their combined diagnostic efficacy was
higher than that of single index ( Z / P = 2． 814 /0． 012，3． 715 / ＜ 0． 001) ． Conclusion The serum albumin level of patients with
·982·疑难病杂志 2023 年 3 月第 22 卷第 3 期 Chin J Diffic and Compl Cas，March 2023，Vol． 22，No． 3

IMN and HUA decreased，γ-The level of GTP increased，which was related to the increase of uric acid level and the occurrence
of HUA．
【Key words】 Idiopathic membranous nephropathy; Hyperuricemia; Albumin; Gamma-glutamyltransferase