The relationship between the expression of miＲ-208a and miＲ-17-5p in serum and left ventricular remodeling and
prognosis in patients with acute myocardial infarction Zhang Lei* ，He Jianxun，Zhang Linlin，Zhai Guangyao，Fan
Xuesong，Yuan Hui． * Clinical Laboratory，Beijing Anzhen Hospital ，Capital Medical University，Beijing 100029，China
Corresponding author: Yuan Hui，E-mail: 18911662931@ 189． cn
Funding program: National Natural Science Foundation of China ( 81902155)
【Abstract】 Objective To analyze the relationship between the expression of microＲNA-208a ( miＲ-208a) and miＲ-
17-5p in serum and left ventricular remodeling ( LVＲ) and prognosis in patients with acute myocardial infarction ( AMI) ．
Methods 133 patients with AMI were selected from the Coronary Heart Disease Center of the Department of Cardiology，Bei-
jing Anzhen Hospital affiliated to Capital Medical University from January to August 2021． According to the left ventricular
end-systolic volume ( LVESV) at the follow-up of 6 months，they were divided into LVＲ group ( 51 cases) and non-LVＲ
group ( 82 cases) ，and were divided into poor prognosis group ( 44 cases) and good prognosis group ( 89 cases) according to
whether major adverse cardiovascular events occurred at the time of 6 months． The expression levels of serum miＲ-208a and
miＲ-17-5p were detected by qPCＲ． The left ventricular end-diastolic diameter ( LVEDD) ，end-diastolic ventricular septal
thickness ( IVST) ，left ventricular posterior wall thickness ( LVPWT) ，left ventricular mass index ( LVMI) and LVESV were
examined by echocardiography． Spearman correlation analysis was used to analyze the correlation between the expression of
miＲ-208a and miＲ-17-5p in serum of patients with LVＲ and LVESV at the time of diagnosis，multivariate logistic regression
·742·疑难病杂志 2023 年 3 月第 22 卷第 3 期 Chin J Diffic and Compl Cas，March 2023，Vol． 22，No． 3

analysis was used to analyze the factors affecting the poor prognosis of patients with AMI，and the working characteristic curve
( ＲOC) of subjects was used to analyze the predictive value of the expression of miＲ-208a and miＲ-17-5p in serum on the poor
prognosis of patients with AMI． Ｒesults The expression levels of serum miＲ-208a and miＲ-17-5p in LVＲ group were higher
than those in non-LVＲ group ( t / Z = 7． 432，10． 964，P ＜ 0． 001) ． LVEDD，IVST，LVPWT，LVMI and LVESV in LVＲ
group were higher than those in non-LVＲ group ( t / Z = 11． 774，8． 611，6． 416，9． 676，5． 336，P ＜ 0． 001) ． The expression
of miＲ-208a and miＲ-17-5p in the poor prognosis group was higher than that in the good prognosis group ( t / Z = 5． 270，5．
376，P ＜ 0． 001) ． Spearman correlation analysis showed that the expression of miＲ-208a and miＲ-17-5p in serum of LVＲ
group was positively correlated with LVESV at the time of diagnosis ( r s = 0． 868，0． 735，P ＜ 0． 001) ． Multivariate logistic re-
gression analysis showed that older age，Killip grade ≥ III，and miＲ-208a，miＲ-17-5p elevation were independent risk factors
for poor prognosis of AMI patients ［OＲ ( 95% CI) = 1． 058 ( 1． 005 － 1． 114) ，4． 984 ( 1． 564 － 15． 880) ，1． 051 ( 1． 007 －
1． 097) ，1． 098 ( 1． 027 － 1． 175) ］，and LVEF elevation was its independent protective factor ［OＲ ( 95% CI) = 0． 932 ( 0．
892 － 0． 975) ］． The ＲOC curve analysis showed that the area under the curve of serum miＲ-208a，miＲ-17-5p and their com-
bination to predict the poor prognosis of patients with AMI were 0． 781，0． 795 and 0． 866，respectively． The value of their
combination prediction was higher than the single index ( Z / P = 2． 102 /0． 025，2． 511 /0． 014) ． Conclusion The increased
expression of miＲ-208a and miＲ-17-5p in serum of patients with AMI is related to LVＲ and poor prognosis，and can be used
as an auxiliary predictor of poor prognosis in patients with AMI．
【Key words】 Myocardial infarction，acute; MicroＲNA-208a; MicroＲNA-17-5p; Left ventricular remodeling; Progno-sis