Clinical observation of Fuxin Heji Decoction combined with metoprolol succinate sustained-release tablets in the treat-
ment of coronary artery myobridge angina Zhang Juan* ，Wu Ji，Wei Xijin，Yang Shiwei． * Affiliated Hospital of Shan-
dong University of Traditional Chinese Medicine，Shandong Province，Jinan 250000，China
Corresponding author: Yang Shiwei，E-mail: ajmermaid@ 163． com
Funding program: Key Support Project of the Joint Fund of Shandong Natural Science Foundation ( ZＲ2021LZY038) ; General
Program of Shandong Natural Science Foundation ( ZＲ2021LZY011 ) ; Shandong Traditional Chinese Medicine Science and
Technology Development Plan ( 2021M180 ) ; Shandong Traditional Chinese Medicine Characteristic Therapy ( 3700020699 ) ;
Shandong Province Science and Technology Ｒesearch Project of the Geriatrics Society( LKJGG2021W106) ; Inheritance project of
Qilu School of Traditional Chinese Medicine Academic Schools( ［2022］93)
【Abstract】 Objective To investigate the clinical effect of Fuxin Heji Decoction combined with metoprolol succinate
sustained release tablets in the treatment of coronary artery myobridge angina． Methods From February 2020 to April 2022，
92 patients with angina pectoris of coronary artery muscle bridge were selected from the Department of Cardiology of the Affilia-
ted Hospital of Shandong University of Traditional Chinese Medicine，Guang＇anmen Hospital of the Chinese Academy of Tradi-
tional Chinese Medicine and Beijing Anzhen Hospital of the Capital Medical University． They were divided into the control
group and the observation group according to the random number table method，with 46 patients in each group． The control
group was treated with metoprolol succinate sustained-release tablets，and the observation group was treated with Fuxin Heji
·352·疑难病杂志 2023 年 3 月第 22 卷第 3 期 Chin J Diffic and Compl Cas，March 2023，Vol． 22，No． 3

Decoction on the basis of the control group，The clinical effects of the two groups were observed，including the score of TCM
syndromes，the index of treadmill exercise electrocardiogram ( the time of angina pectoris during exercise，the time of ST seg-
ment moving down 0． 1 mV) ，the score of the Seattle Angina Scale ( SAQ) ，the vascular endothelial function ( serum endothe-
lin ( ET-1) ，nitric oxide ( NO) ，and the vascular endothelial function index ( ＲHI) before and after treatment． Ｒesults Af-
ter 2 months of treatment，the total effective rate of the observation group was significantly higher than that of the control group
( 89． 13% vs 76． 09% ，χ2 / P = 7． 568 /0． 023) ． After 2 months of treatment，the scores of chest tightness or chest pain，short-
ness of breath，insomnia，and anorexia in the two groups were lower than those before treatment，and the observation group
was lower than the control group ( t / P = 3． 318 /0． 001，4． 511 / ＜ 0． 001，2． 209 /0． 030，2． 142 /0． 035) ． After 2 months of
treatment，the time of exercise angina pectoris，the time of movement ST segment downward 0． 1 mV，and the SAQ score ( the
degree of physical activity restriction，the stable state of angina pectoris，the incidence of angina pectoris，the degree of treat-
ment satisfaction，and the degree of disease cognition) in the two groups were higher than those before treatment，and the ob-
servation group was higher than the control group ( t / P = 4． 715 / ＜ 0． 001，6． 736 / ＜ 0． 001，2． 844 /0． 006，2． 293 /0． 024，3．
190 /0． 002，6． 084 / ＜ 0． 001，2． 229 /0． 028) ． After 2 months of treatment，the level of ET-1 in both groups was lower than
that before treatment，and the level of NO and ＲHI index were higher than those before treatment，and the observation group
was better than the control group ( t / P = 8． 213 / ＜ 0． 001，3． 073 /0． 003，2． 472 /0． 015) ． Conclusion Fuxin Heji Decoction
combined with metoprolol succinate sustained-release tablets has a significant clinical effect on patients with coronary artery
myobridge angina．
【Key words】 Coronary myocardial bridge; Angina; Fuxin Heji Decoction; Metoprolol succinate sustained-release tab-
lets; Clinical effect