Correlation between serum ITLN-1，ANGPTL4 levels and severity of coronary artery disease in patients with acute
myocardial infarction Tian Yuan，Feng Jun，Huang Haitao，Zhang Meihua，Sun Zhaojin，Yu Shicheng，Ding Shengkai，
Li Fengyun，Zhang Mengda，Xu Pan，Ma Lingling． Department of Cardiovascular Medicine，Lu’an Affiliated Hospital of An-
hui Medical University，Anhui Province，Liu’an，237000，China
Corresponding author: Feng Jun，E-mail: fengbenjun2009@ 163． com
Funding program: Anhui Provincial Key Ｒesearch and Development Program ( 1704f0804045)
【Abstract】 Objective To observe the expression level of serum agglutinin 1 ( ITLN-1) and angiopoietin-like protein
4 ( ANGPTL4) in patients with acute myocardial infarction ( AMI) ，and explore the correlation between them and the degree
of coronary artery disease． Methods From June 2019 to July 2021，128 patients with AMI admitted by the Department of
Cardiovascular Medicine of Lu＇an Hospital affiliated to Anhui Medical University were selected as the study group，and 120 pa-
tients with physical examination in the same period were selected as the health control group． According to the Gensini score of
coronary artery disease，the patients in the study group were divided into 35 mild subgroups ( Gensini score ＜ 18) ，43 moder-
ate subgroups ( Gensini score 18-40) ，and 50 severe subgroups ( Gensini score ＞ 40) ． The clinical data of the subjects were
collected and the serum levels of ITLN-1 and ANGPTL4 were detected by enzyme-linked immunosorbent assay． Pearson meth-
od was used to analyze the correlation between serum ITLN-1，ANGPTL4 and Gensini score． Logistic regression analysis was
used to analyze the factors affecting the degree of coronary artery disease． Ｒesults The left ventricular ejection fraction
( LVEF) of the study group was lower than that of the healthy control group，and the high sensitivity C-reactive protein ( hs-
CＲP) ，B-type brain natriuretic peptide ( BNP) ，left ventricular end-diastolic diameter ( LVEDD) were higher than those of
·632· 疑难病杂志 2023 年 3 月第 22 卷第 3 期 Chin J Diffic and Compl Cas，March 2023，Vol． 22，No． 3

the healthy control group ( t / P = 9． 368 / ＜ 0． 001，2． 810 /0． 005，8． 229 / ＜ 0． 001，7． 006 / ＜ 0． 001) ; The levels of serum
ITLN-1 and ANGPTL4 in the study group were lower than those in the healthy control group ( t / P = 8． 170 / ＜ 0． 001，7． 986 /
＜ 0． 001) ，and the levels of serum ITLN-1 and ANGPTL4 in patients with AMI in the mild subgroup，the moderate subgroup
and the severe subgroup decreased in turn ( F = 38． 240，16． 527，P ＜ 0． 001) ; Pearson analysis showed that serum ITLN-1
and ANGPTL4 were negatively correlated with Gensini score ( r = － 0． 397，－ 0． 429，P ＜ 0． 001) ; Logistic regression analysis
showed that low ITLN-1，low ANGPTL4，high BNP，high LVEDD and low LVEF were risk factors for the severity of coronary
artery disease in AMI patients ［OＲ ( 95% CI) = 2． 103 ( 1． 136 － 3． 892) ，2． 114 ( 1． 170 － 3． 821) ，1． 514 ( 1． 068 － 2．
146) ，2． 514 ( 1． 340 － 4． 716) ，2． 624 ( 1． 134 － 6． 071) ］． Conclusion The expression of ITLN-1 and ANGPTL4 in serum
of patients with AMI was low，which was closely related to the degree of coronary artery disease．
【Key words】 Acute myocardial infarction; Intelectin-1; Angiopoietin like protein 4; Degree of coronary artery dis-ease; Correlation