Ｒelationship between serum HDAC2，SFＲP2 levels and ventricular remodeling in elderly patients with chronic heart
failure Lu Ziwang，Li Fei，Chen Wanlin，Zhang Chunying． Department of Cardiovascular Internal Medicine，Baoji People＇s
Hospital，Shaanxi Province，Baoji 721000，China
Corresponding author: Li Fei，E-mail: thbco63@ 163． com
Funding program: National Natural Science Foundation of China ( 81770345)
【Abstract 】 Objective To investigate the relationship between the expression of serum histone deacetylase 2
( HDAC2) ，secretory curl associated protein 2 ( SFＲP2) and ventricular remodeling in elderly patients with chronic heart fail-
ure ( CHF) ． Methods One hundred and seventeen elderly patients with CHF diagnosed and treated by the First Department
of Cardiology of Baoji People＇s Hospital from January 2021 to June 2022 were selected as the CHF group． According to the
classification of cardiac function，they were divided into 47 cases of grade II，38 cases of grade III，and 32 cases of grade IV;
120 healthy people were selected as the healthy control group． The levels of serum HDAC2 and SFＲP2 were detected by
ELISA，and the indexes related to cardiac function ( left atrial diameter ( LAD ) ，left ventricular end-diastolic diameter
( LVEDD) ，left ventricular mass index ( LVMI) ，left ventricular ejection fraction ( LVEF) ，and left ventricular remodeling
index ( LVＲI) ) were examined by echocardiography The diagnostic value of SFＲP2 for CHF． Ｒesults The serum levels of
HDAC2 and N-terminal pro-brain natriuretic peptide ( NT-proBNP) in CHF group were significantly higher than those in
healthy control group，and the level of SFＲP2 was significantly lower than that in healthy control group ( t( Z) / P = 14． 476 / ＜
·132·疑难病杂志 2023 年 3 月第 22 卷第 3 期 Chin J Diffic and Compl Cas，March 2023，Vol． 22，No． 3

0． 001，17． 465 / ＜ 0． 001，23． 903 / ＜ 0． 001) ; The serum HDAC2 level was compared with Grade II ＜ Grade III ＜ Grade
IV ( F / P = 54． 632 / ＜ 0． 001) ，and the serum SFＲP2 level was compared with Grade II ＞ Grade III ＞ Grade IV ( F / P =
78． 503 / ＜ 0． 001) ． LAD，LVEDD and LVMI in CHF group were significantly higher than those in healthy control group，and
LVEF and LVＲI were significantly lower than those in healthy control group ( t / P = 15． 221 / ＜ 0． 001，14． 824 / ＜ 0． 001，9．
728 / ＜ 0． 001，20． 848 / ＜ 0． 001，8． 335 / ＜ 0． 001) ; Compared with LAD，LVEDD and LVMI，Level II ＜ Level III ＜ Lev-
el IV ( F / P = 71． 571 / ＜ 0． 001，45． 980 / ＜ 0． 001，16． 697 / ＜ 0． 001) ，LVEF and LVＲI，Level II ＞ Level III ＞ Level
IV ( F / P = 101． 017 / ＜ 0． 001，16． 544 / ＜ 0． 001) ． Pearson analysis showed that serum HDAC2 was positively correlated
with LAD，LVEDD，LVMI and NT-proBNP ( P ＜ 0． 01) ，and negatively correlated with LVEF and LVＲI ( P ＜ 0． 01) ; Serum
SFＲP2 was negatively correlated with LAD，LVEDD，LVMI and NT-proBNP ( P ＜ 0． 01 ) ，and positively correlated with
LVEF and LVＲI ( P ＜ 0． 01) ． The ＲOC curve results showed that the area under the curve ( AUC) of serum HDAC2，SFＲP2
and their combined prediction of CHF were 0． 827，0． 865 and 0． 931，respectively． The combined prediction efficiency of the
two was higher than that of independent detection ( Z / P = 3． 258 /0． 001，2． 286 /0． 022) ． Conclusion The increase of serum
HDAC2 level and the decrease of SFＲP2 level in patients with CHF are related to ventricular remodeling，which can be used
as a clinical auxiliary index to evaluate the condition of patients with CHF．
【Key words】 Chronic heart failure; Histone deacetylase 2; Secreted frizzled-related protein 2; Ventricular remode-ling; Elderly