A large number of endogenous substances and toxic components in blood released after intracerebral hemor-
rhage can destroy the blood-brain barrier，aggravate inflammatory reaction and brain edema，and seriously affect the prognosis
of patients with intracerebral hemorrhage． The level of microＲNAs changes after intracerebral hemorrhage，which can regulate
the function of blood-brain barrier through various mechanisms． This review summarizes the research progress of the effect of
microＲNAs on blood-brain barrier after intracerebral hemorrhage in order to find more effective treatment methods for patients
with hemorrhagic stroke．

Pyroptosis, as an inflammatory regulatory cell death, plays an important role in the process of organism's defense against foreign pathogens as well as other disease. The specific mechanism of pyroptosis through Caspase activation has made breakthrough progress in recent years. GSDMD protein, as a Caspase substrate, cleaved and perforated the cell membrane to induce pyroptosis. The role of other GSDMs family proteins in pyroptosis has also been gradually elucidated. Pyroptosis has been recognized as a programmed death process mediated by GSDM family proteins.