Fluoxetine is currently a widely used antidepressant, which can cause adverse reactions such as hepatitis, skin diseases, sexual dysfunction, drowsiness, dizziness, etc. during the treatment process. However, the preclinical experimental research on its induced adverse reactions is currently limited. The preclinical experimental research on adverse reactions induced by fluoxetine mainly focuses on the study of fluoxetine induced liver injury in rats and its reduction in toxicity. The toxicity mechanism involves oxidative stress, inflammatory response, cell apoptosis, etc. However, it is still unclear to date. This article reviews the research on the toxic mechanism and detoxification strategies of fluoxetine induced liver injury, in order to provide literature support and inspiration for the safe use of fluoxetine