Triple negative breast cancer(TNBC) is a special type of breast cancer, which has a high recurrence rate and invasion rate. Recent studies have found that abnormal expression of long non-coding RNA(lncRNA) in TNBC can participate in biological processes such as proliferation, differentiation, migration, autophagy and apoptosis of TNBC cells through multi-gene or multi-signal transduction pathways, and play an important role in the occurrence and development of TNBC. The molecular mechanism of action regulated by lncRNA is currently a hot topic in TNBC research, which can be used to assist diagnosis and prognosis prediction, and is expected to become a potential target of TNBC. This article reviews the characteristics of lncRNA, its specific mechanism of action in TNBC and its prognosis.

Adrenocortical carcinoma is a rare malignant tumor with poor prognosis and is highly aggressive. It is clinically more common in female patients. The cause of this disease has not yet been fully elucidated, but it may be related to organ dysfunction, dietary factors, and drug factors. It often manifests as virilization in females and hyperfunction of the adrenal glands. Due to the strong invasiveness of adrenocortical carcinoma and its propensity for metastasis, common lymphatic metastases mainly involve the lymph nodes around the adrenal glands and the large arteries. Therefore, early detection and complete surgical resection are key to treating the disease, with the aim of removing as much of the tumor and adjacent tissue as possible to increase the success rate of treatment. For patients with adrenocortical carcinoma who have distant metastases or poor general condition and are not candidates for surgery, adjunctive therapies such as radiotherapy, chemotherapy, and molecular targeted therapy may be considered to prolong survival. This article presents a comprehensive and systematic review of the latest basic and clinical research advances in the treatment of adrenocortical carcinoma. The aim is to provide new perspectives and experiences in the clinical treatment of adrenocortical carcinoma.

The human immune system maintains dynamic balance at all times. When the immune system is disordered, it can lead to acute and chronic inflammatory diseases, autoimmune diseases, graft versus host disease(GVHD) and other immune-related diseases. Regulatory T cells(Treg) are a subset of CD4+ helper T cells, which play an important role in maintaining immune homeostasis and preventing autoimmune diseases. In view of this, the article reviews the physiological mechanism, immunotherapy methods and the value of targeted therapy of Treg cells, aiming to provide useful reference for the subsequent immunotherapy strategies of Treg cells.