Hypertensive disease needs long-term or even lifelong medication has become a reality that patients do not want to accept and have to accept. It is the common desire of scholars and patients to seek ways to delay the occurrence and development of hypertension. The pathologic process of hypertension is complex, and stable hypertension requiring long-term drug control is accompanied by significant remodeling of vascular structure, and the irreversibility of remodeling results is the key to long-term drug control. Early hypertension(EH) is a transitional period between stable hypertension and normal blood pressure, characterized by high blood pressure that can be recovered by improving life style. Pathological changes are mainly manifested as vascular endothelial dilation dysfunction, which is the initial stage of vascular remodeling such as atherosclerosis. However, the reversible characteristics of EH vascular remodeling may be a new target for the prevention and treatment of hypertension. This article reviews the internal mechanism of EH vascular remodeling, and provides new ideas for the early prevention and treatment of hypertension and related vascular diseases.

The incidence of Vascular dementia(VaD) is increasing globally due to the aging population and dietary changes, posing a significant burden on families and society. It has emerged as a pressing public health concern that jeopardizes the physical and mental well-being of middle-aged and elderly individuals. The etiology and pathogenesis of VaD are intricate and not yet fully understood. This review explores the pathogenesis of VaD, as well as the potential mechanisms underlying acupuncture treatment for VaD, including cholinergic system function, glutamate neurotoxicity, oxidative stress injury, inflammatory response, apoptosis, synaptic plasticity, expression of neuroprotective factors, and Aβ injury mechanism. These findings aim to offer insights for the clinical application of acupuncture in treating VaD.

The serrated pathway is one of the important routes of occurrence of colorectal cancer. Sessile serrated lesions with dysplasia(SSLD) are an intermediate stage between serrated sessile lesion(SSL) and invasive colorectal cancer, with significant clinical significance. However, due to its flat morphology and rapid progression, detecting and diagnosing SSLD is particularly difficult, leading to the occurrence of interval cancers. With increasing evidence, their characteristics and biological characteristics have been clarified. This article comprehensively summarizes the research progress on the endoscopic manifestations, histopathological features, molecular mechanisms, microenvironment, and treatment of SSLD at home and abroad, with the aim of providing theoretical basis for the clinical diagnosis and treatment of SSLD.