Objective To investigate the serum interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) in patients with subclinical hypothyroidism(SCH) during pregnancy. The relationship between the expression of insulin-like growth factor-1(IGF-1) and blood lipid, thyroid function and pregnancy outcome. Methods From March 2018 to September 2020, 52 patients with SCH were selected as the observation group in the Obstetrics Department of the Second Affiliated Hospital of Xinjiang Medical University, and were divided into 42 normal pregnancy subgroups and 10 poor pregnancy subgroups according to the pregnancy outcome. In addition, 35 non-SCH pregnant women in the same period were selected as the control group. Observe and compare the serum IL-6 and TNF-α of pregnant women in each group, IGF-1 level and blood lipid [total cholesterol(TC), triacylglycerol(TG), low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol(HDL-C)], fasting blood glucose(FPG), renal function [blood urea nitrogen(BUN), creatinine(SCR), uric acid(UA)] and thyroid function indicators [thyroid stimulating hormone(TSH), free triiodothyronine(FT₃), free thyroid hormone(FT₄)]. Analysis of serum IL-6 and TNF-α in pregnant women with SCH, the relationship between IGF-1 level and blood lipid, thyroid function.Results Compared with the control group, the serum IL-6 and TNF-α of pregnant women in the observation group, the levels of TC, TG, LDL-C and TSH increased significantly(t/P=4.697/<0.001, 5.815/< 0.001, 2.311/0.023, 2.214/0.030, 3.168/0.002, 2.245/0.027), while the levels of IGF-1 decreased significantly(t/P=2.959/0.004); There was no significant difference in HDL-C, FPG, BUN, SCR, UA, FT₄ and FT₃ between the two groups(P>0.05). Serum IL-6 and TNF-α of pregnant women in poor pregnancy subgroup The level of IGF-1 was significantly higher than that of normal pregnancy subgroup(t/P=2.706/0.009, 2.105/0.040), while the level of IGF-1 was significantly lower than that of normal pregnancy subgroup(t/P=2.335/0.024). Pearson correlation analysis showed that serum IL-6 and TNF-α were positively correlated with TC, TG, LDL-C, HDL-C, TSH, FT₄, FT₃ levels, while IGF-1 was negatively correlated with TSH(P<0.05). Conclusion The level of serum IL-6 and TNF-α in patients with SCH increased and the level of IGF-1 decreased, which was related to blood lipid, thyroid function and adverse pregnancy outcome.

Subclinical hypothyroidism,pregnancy;                    Interleukin-6;                    Tumor necrosis factor-α;                    Insulin-like growth factor-1;                    Blood lipid;                    Thyroid function;                    Pregnancy outcomes;                    Correlation;