Study on the relationship between serum PECAM-1，GDF11，FGF21 and cerebral artery hemodynamics and carotid
atherosclerosis in patients with lacunar cerebral infarction Wang Xiaohui* ，Chen Hongnan，Jiang Feng，Chang Sha，
Wang Le，Cui Xiaoli． * Department of Internal Medicine Neurology，Shaanxi Provincial People＇s Hospital，Shaanxi Province，Xi
＇an 710068，China
Corresponding author: Cui Xiaoli，E-mail: lili6416669 @ 126． com
Funding program: The 2021 Science and Tchnology Planning Project of Shaanxi Province ( 2021QJ-229)
【Abstract】 Objective To analyze the relationship between serum platelet endothelial cell adhesion molecule-1 ( PE-
CAM-1) ，growth differentiation factor 11 ( GDF11) ，fibroblast growth factor 21 ( FGF21) and cerebral artery hemodynamics
and carotid atherosclerosis in patients with lacunar cerebral infarction． Methods From January 2020 to January 2022，160
patients with lacunar cerebral infarction admitted to the Department of Neurology of Shaanxi Provincial People＇s Hospital were
selected as the cerebral infarction group，and were divided into carotid atherosclerosis subgroup and normal carotid artery sub-
group according to carotid artery intima-media thickness ( IMT) ． In addition，100 patients with health examination at the same
time were selected as the healthy control group，and the serum PECAM-1，GDF11，FGF21 levels and cerebral artery hemody-
·852· 疑难病杂志 2023 年 3 月第 22 卷第 3 期 Chin J Diffic and Compl Cas，March 2023，Vol． 22，No． 3

namic parameters of the two groups were compared，Pearson linear correlation was used to analyze the correlation between ser-
um PECAM-1，GDF11，FGF21 and cerebral artery hemodynamic parameters in patients with lacunar infarction． Logistic multi
factor regression was used to analyze the influencing factors of carotid atherosclerosis in patients with lacunar cerebral infarc-
tion，and the receiver operating characteristic curve ( ＲOC) was drawn to analyze the diagnostic value of serum PECAM-1，
GDF11，FGF21 levels for carotid atherosclerosis． Ｒesults Serum PECAM-1 and FGF21 in cerebral infarction group were
higher than those in healthy control group，and serum GDF11 was lower than that in healthy control group ( t = 8． 386，17．
511，6． 795，P ＜ 0． 001) ． The pulsation index of middle cerebral artery and basilar artery in cerebral infarction group was
higher than that in healthy control group ( t = 16． 928，7． 686，P ＜ 0． 001) ． The levels of serum PECAM-1 and FGF21 in pa-
tients with lacunar infarction were positively correlated with the pulsation index of middle cerebral artery and basilar artery
( PECAM-1: r = 0． 537，0． 462，P ＜ 0． 001; FGF21: r = 0． 569，0． 503，P ＜ 0． 001) ，while the levels of serum GDF11 were
negatively correlated with the pulsation index of middle cerebral artery and basilar artery ( r = － 0． 512， － 0． 498，P ＜ 0．
001) ． Logistic regression analysis showed that hypertension history，high low-density lipoprotein cholesterol ( LDL-C) ，high
PECAM-1，and high FGF21 were risk factors for carotid atherosclerosis in patients with lacunar cerebral infarction ［OＲ ( 95%
CI) = 3． 654 ( 1． 601 － 8． 343) ，2． 481 ( 1． 508 － 4． 085) ，1． 073 ( 1． 032 － 1． 114) ，1． 024 ( 1． 011 － 1． 038) ，P ＜ 0． 01］，
and high serum high-density lipoprotein cholesterol ( HDL-C) High GDF11 was the protective factor ［OＲ ( 95% CI) = 0． 781
( 0． 613 － 0． 995) ，0． 992 ( 0． 987 － 0． 997) ，P ＜ 0． 05］． ＲOC curve showed that the area under the curve ( AUC) of serum
PECAM-1，GDF11，FGF21 and their combined assessment of the risk of carotid atherosclerosis were 0． 798，0． 716，0． 813，
0． 909，respectively，and their combined assessment efficiency was higher than that predicted by single index ( Z / P = 2． 097 /
0． 036，2． 290 /0． 022，2． 005 /0． 045) ． Conclusion Serum PECAM-1，GDF11，FGF21 levels in patients with lacunar cere-
bral infarction are related to cerebral artery hemodynamic parameters，which is of great significance in the evaluation of carotid
atherosclerosis．
【Key words】 Lacunar cerebral infarction; Platelet endothelial cell adhesion molecule-1; Growth differentiation factor
11; Fibroblast growth factor 21; Cerebral artery hemodynamics; Carotid atherosclerosis; Correlation