Transient receptor potential ( TＲP) channels are widely expressed in mammalian tissues and cells，and
play multiple roles in inflammatory response，immunity，sensory conduction，etc． The abnormality of their functional status is
closely related to the occurrence of diseases． In recent years，a number of studies have shown that TＲP channels are involved
in the occurrence and development of esophagus-related diseases． Therefore，this article reviews the role and mechanism of
TＲP channel in esophageal diseases，looks forward to its application prospects in the treatment of esophageal diseases，and
provides new ideas for future clinical treatment．

Dipeptidyl peptidase-4 ( DPP-4) is expressed in a variety of immune cells and is involved in the regulation
of immune function，and has a high affinity for the spike receptor binding region of severe acute respiratory syndrome coronavirus 2 ( SAＲS-CoV-2) ． And，therefore，SAＲS-CoV-2 can enter the host through DPP 4 as a functional receptor． Dipeptidyl
peptidase 4 inhibitors ( DPP-4is) have anti-inflammatory properties that can benefit the body by reducing cytokine storm and
slowing disease progression． DPP-4is occupies an important position in the treatment of type 2 diabetes mellitus ( T2DM) due
to its favorable efficacy and safety profile． This article reviews the research progress on the relationship between the use of DPP
4is and clinical prognosis in diabetic patients infected with SAＲS-CoV-2

In recent years，with the rise of research on the mechanism of paraneoplastic syndrome，the manifestations
and pathogenesis of nervous system paraneoplastic syndrome ( PNS) have become the focus of clinical research． Paraneoplastic
syndrome of the nervous system refers to a group of clinical syndromes in which the products of tumors act on the common antigens of the nervous system in the body and cross immune reactions affect the nervous system，such as cerebral cortex，cerebellum，brain stem，and peripheral nerves，causing corresponding neurological deficits． Such patients often have acute or subacute onset and poor prognosis． At present，the systematic research on the antineoplastic antibodies of the nervous system is still
insufficient，and understanding the immune response of the antineoplastic antibodies of the nervous system to the body is the
key to formulate corresponding treatment strategies． This article reviews the origin，pathogenesis，clinical manifestations，diagnosis，treatment and prognosis of anti Ｒi antibody positive PNS patients．