To analyze the relationship between serum sulfatide, decoy receptor 3(DcR3) and myocardial injury and short-term major adverse cardiovascular events(MACE) in patients with acute ST segment elevation myocardial infarction(STEMI). Methods From January 2020 to January 2021, 102 patients with STEMI who underwent PCI in the Cardiovascular Department of Zhangjiakou First Hospital were selected as the study object(case group), and 60 health examinees in the same hospital were selected as the health control group. STEMI patients were followed up for 1 year after PCI, and were divided into MACE subgroup(27 cases) and non-MACE subgroup(75 cases) according to whether the patients had MACE. Serum levels of Sulfatide, DcR3, troponin I(cTnI), creatine kinase isoenzyme(CK-MB), myoglobin(Mb) and N-terminal pro brain natriuretic peptide(NT-proBNP) were measured in the two groups; Pearson product moment correlation was used to analyze the relationship between serum Sulfatide, DcR3 and cTnI, CK-MB, Mb, NT-proBNP. Multivariate logistic regression analysis was used to analyze the influencing factors of MACE in STEMI patients; The predictive value of serum Sulfatide and DcR3 on the occurrence of MACE in patients with STEMI was evaluated by drawing the receiver operating characteristic curve(ROC). Results The serum Sulfatide level in the case group was higher than that in the healthy control group, and the DcR3 level was lower than that in the healthy control group(t/P=19.347/<0.001, 18.537/<0.001). Serum cTnI, CK-MB, Mb, NT-proBNP levels were higher than those in the healthy control group(t/P=29.002/<0.001, 69.953/<0.001, 38.189/<0.001, 28.937/<0.001). Serum cTnI, CK-MB, Mb, NT-proBNP in STEMI patients were positively correlated with Sulfatide(r/P=0.683/0.006, 0.762/0.001, 0.736/0.001, 0.720/0.001), and negatively correlated with DcR3(r/P=-0.637/0.008,-0.729/0.001,-0.715/0.001,-0.702/0.003). Multivariate logistic regression analysis showed that high cTnI, CK-MB, Mb, NT-proBNP, and Sulfatide were risk factors for the occurrence of MACE in patients with STEMI [OR(95% CI)=1.420(1.009-1.782), 1.346(1.016-1.624), 1.365(1.011-1.598), 1.493(1.112-1.890), 1.692(1.203-1.937)], and high DcR3 was a protective factor [OR(95% CI)=0.850(0.792-0.938)]. The area under the curve(AUC) of serum Sulfatide, DcR3 and their combination to predict the occurrence of MACE in STEMI patients were 0.826, 0.797 and 0.890, respectively. The combined predictive value of the two indicators was greater than that of a single indicator(Z/P=2.359/0.043, 3.216/0.032). Conclusion The increase of serum Sulfatide and the decrease of serum DcR3 in patients with STEMI are closely related to myocardial injury. Both of them can be used as auxiliary biochemical markers to predict the short-term occurrence of MACE in patients with STEMI after PCI.

Objective To observe the effect of Shensongyangxin capsule on sinus rhythm maintenance, left ventricular function and quality of life in patients with persistent atrial fibrillation after radiofrequency ablation. Methods From May 2019 to June 2021, 60 patients with persistent atrial fibrillation who underwent radiofrequency ablation and converted to sinus rhythm in the Cardiovascular Department of the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine were selected. They were randomly divided into the conventional group and the combined group, with 30 patients in each group. The patients in the conventional group were treated with basic scheme after operation, and the patients in the combined group were treated with Shensongyangxin capsule on the basis of the conventional group. Three months was one course of treatment, and two courses of treatment. At the end of each course of treatment, the patients' dynamic electrocardiogram and cardiac color ultrasound indexes were monitored and the scores of atrial fibrillation specific quality of life scale(AFEQT) were counted. Sinus heart rate maintenance, left atrial diameter, left ventricular ejection fraction(LVEF) and adverse reactions were compared between the two groups. Results Six months after operation, the total effective rate of the combined group was higher than that of the conventional group(90.0% vs.83.3%, χ2=6.825,P=0.033).Three months after operation, the total score of the AFEQT scale and the scores of four dimensions(symptom dimension, daily activity dimension, treatment anxiety dimension, treatment satisfaction dimension) of the two groups were higher than those before treatment(P<0.05), and the scores of the combined group in the treatment anxiety dimension were higher than those of the conventional group(P<0.05). Six months after operation, the total score and four-dimension scores of the AFEQT scale in both groups were higher than those before operation(P<0.05), and those in the combined group were higher than those in the conventional group(t/P=10.311/<0.001, 6.139/<0.001, 5.763/<0.001, 3.076/0.005, 4.899/<0.001). 3="" 6="" there="" was="" no="" significant="" difference="" in="" the="" maintenance="" rate="" of="" sinus="" rhythm="" between="" two="" groups="" at="" and="" months="" after="" p="">0.05). Three months after operation, the left atrial diameter in the combined group was smaller than that before operation, and significantly smaller than that in the conventional group(t/P=4.187/<0.001). LVEF in both groups was higher than that before operation(P<0.05), but="" there="" was="" no="" significant="" difference="" between="" the="" two="" p="">0.05). Six months after operation, the left atrial diameter in both groups was smaller than that before operation, and LEVF was higher than that before operation(P<0.05). lvef="" in="" the="" combined="" group="" was="" significantly="" higher="" than="" that="" conventional="" p="" but="" there="" no="" significant="" difference="" left="" atrial="" diameter="" between="" two="">0.05).Conclusion Shensongyangxin capsule can reduce the left atrial diameter, improve LVEF and improve the quality of life of patients with persistent atrial fibrillation after radiofrequency ablation.

Objective To explore the effect of sodium glucose cotransporter 2(SGLT-2) inhibitor on major cardiovascular risk factors in type 2 diabetes(T2DM) patients. Methods One hundred and forty four T2DM patients admitted to the Department of Cardiology of General Hospital of Angang Steel Group from October 2019 to October 2021 were selected as the research objects, and were divided into control group and observation group according to the random number table, with 72 patients in each group. The control group was treated with routine therapy, and the observation group was treated with SGLT-2 inhibitor(daggligin) on the basis of the control group. Obesity index [body mass index(BMI), waist hip ratio(WHR)], blood pressure level [systolic blood pressure(SBP), diastolic blood pressure(DBP)], blood glucose index [fasting blood glucose(FPG), glycosylated hemoglobin(HbA1c), blood glucose in 2h after meal(2hPG)], blood lipid level [total cholesterol(TC), low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol(HDL-C), triacylglycerol(TG)] Levels of inflammatory related factors [C-reactive protein(CRP), interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), Levels of homocysteine(Hcy)], adiponectin(APN), leptin(LP), resistin, and adverse reactions. Results Compared with that before treatment, the levels of BMI, WHR, SBP and DBP in the two groups decreased after 3 months of treatment, and the levels in the observation group were lower than those in the control group(t/P=3.036/0.003, 4.346/<0.001, 5.088/<0.001, 4.225/<0.001). The levels of FPG, HbA1c and 2hPG in the two groups were lower than those in the control group(t=4.323, 3.884, 4.159, P<0.001). The levels of TC, LDL-C and TG in both groups decreased, and HDL-C levels increased, and the improvement in the observation group was better than that in the control group(t/P=3.669/<0.001, 3.278/0.001, 3.781/<0.001, 2.458/0.015). Serum CRP, IL-6, TNF-α, the level of Hcy in the observation group was lower than that in the control group(t/P=4.795/<0.001, 3.325/0.001, 3.229/0.002, 4.032/<0.001). The serum APN in both groups increased, the levels of LP and resistin decreased, and the improvement in the observation group was better than that in the control group(t/P=4.097/<0.001, 5.690/<0.001, .="" there="" was="" no="" significant="" difference="" in="" the="" incidence="" of="" adverse="" reactions="" between="" two="" p="">0.05). Conclusion The addition of SGLT-2 inhibitor on the basis of routine treatment can further control the major cardiovascular risk factors of T2DM, reduce the inflammatory reaction of the body, regulate the expression of fat factors, reduce the incidence of adverse vascular events, and has good safety.

Objective To detect the expression of C-X-C chemokine ligand 1(CXCL1), signal transducer and activator of transcription 1(STAT1) in the plasma of patients with DeBakey type I aortic dissection(AD), and analyze their relationship with the prognosis. Methods From July 2018 to April 2020, 63 patients with DeBakey type I AD admitted to the cardiac surgery Department of Qinghai Cardio Cerebrovascular Hospital were selected as the observation group. According to the prognosis outcome of one year after discharge, they were divided into a subgroup of 46 patients with good prognosis and a subgroup of 17 patients with poor prognosis. In addition, 63 patients with physical examination at the same time were selected as the health control group. The expression of CXCL1 and STAT1 in plasma was detected by ELISA. Logistic regression analysis was used to analyze the factors affecting the prognosis of DeBakey type I AD patients. The predictive value of the plasma CXCL1 and STAT1 levels assessed by the receiver operating characteristic curve(ROC) on the prognosis of DeBakey type I AD patients. Results Compared with the healthy control group, the expression levels of CXCL1 and STAT1 in plasma of patients in the observation group were significantly higher(t/P=31.396/<0.001, 10.567/<0.001). Compared with the subgroup with good prognosis, the expression levels of CXCL1 and STAT1 in plasma of DeBakey type I AD patients with poor prognosis were significantly higher(t/P=6.327/<0.001, 6.298/<0.001). Elevated plasma CXCL1 and STAT1 levels were risk factors for poor prognosis in DeBakey type I AD patients [OR(95%CI)=1.403(1.100-1.789),1.295(1.052-1.594), all P<0.05].The area under the ROC curve of plasma CXCL1, STAT1 alone and their combination to predict the prognosis of DeBakey type I AD patients were 0.891, 0.886 and 0.968, respectively. The value of their combination to predict the prognosis of DeBakey type I AD patients was higher than that of single prediction, but the difference was not statistically significant(Z/P=1.547/0.061,1.432/0.076). Conclusion The expression of CXCL1 and STAT1 in plasma of DeBakey type I AD patients increased, which was related to the prognosis. Both of them had a certain predictive value for the prognosis, and the combined predictive value was higher.

Objective To analyze the relationship between myocardial injury, hemodynamics and cardiac structure and function in sepsis patients with myocardial dysfunction. Methods Two hundred and two patients with sepsis diagnosed and treated by the Department of Critical Care Medicine of Hebei PetroChina Central Hospital from December 2017 to December 2019 were selected. According to whether there is myocardial dysfunction, 142 cases were divided into sepsis group and 60 cases into sepsis group with myocardial dysfunction(complication group). Myocardial injury indexes(NT-proBNP, MYO and cTNI), hemodynamic indexes(SBP, MAP, DBP, HR and SpO2), cardiac structure and function indexes(peak left ventricular early diastolic filling velocity(E peak), peak left ventricular late diastolic filling velocity(A peak), ratio of mitral E peak to A peak(E/A) LVEF, LVESD, LVEDD, FS, IVS. Pearson method was used to analyze the relationship between myocardial injury, hemodynamic indexes and cardiac structure and function. The mortality of the two groups was compared after 30 days of follow-up. Results Compared with sepsis group, the levels of NT-proBNP, MYO and cTNI in serum of patients with complications were significantly higher(t=4.183, 4.473, 6.351, P<0.001). The levels of SBP, MAP and SpO2 decreased, and HR increased significantly(t=4.351, 2.084, 5.956, 4.460, P<0.001). E peak, E/A, LVEF, LVESD, LVEDD decreased significantly(t=3.973, 3.856, 8.100, 14.497, 15.139, all P<0.001), FS, IVS increased significantly(t=18.834, 11.176, all P<0.001), and="" there="" was="" no="" significant="" difference="" between="" dbp="" a="" peak="" the="" two="" p="">0.05). Pearson analysis showed that NT-proBNP, MYO, cTNI, HR were negatively correlated with E peak, E/A, LVEF, LVESD, LVEDD(P<0.01), and positively correlated with A peak, FS, IVS(P<0.01). SBP, DBP, MAP and SpO2 were positively correlated with E peak, E/A, LVEF, LVESD and LVEDD(P<0.05), and negatively correlated with A peak, FS and IVS(P<0.05). Compared with sepsis group, the mortality of complication group was significantly higher(χ2=5.424,P=0.020). Conclusion Sepsis patients with myocardial dysfunction are accompanied by changes in hemodynamics, myocardial injury, cardiac structure and function. Myocardial injury and hemodynamic changes have a linear relationship with cardiac structure and function. Sepsis patients with myocardial dysfunction have a poor prognosis.