Objective To explore the effects and mechanisms of the cAMP/CREB signaling pathway on cognitive and memory impairment induced by propofol anesthesia in rats. Methods From December 2021 to February 2022, an experiment was conducted in the Animal Laboratory of Enshi Tujia and Miao Autonomous Prefecture Central Hospital in Hubei Province. Thirty rats were randomly divided into a control group, a propofol group, and a group of 10 rats each containing 8-Br-cAMP and propofol. The 8-Br-cAMP+propofol group was injected with the signal pathway agonist 8-Br-cAMP+propofol, while the propofol group was injected with propofol and the control group was injected with 0.9% sodium chloride. Observe the changes in cognitive and memory function of rats after 1 day of anesthesia. Results Compared with the control group, the propofol group rats had a longer escape latency time and a lower number of crossing platforms(P<0.01 for all); Compared with the propofol group, the rats in the 8-Br-cAMP+propofol group had a shorter escape latency time and an increase in the number of crossing platforms(P<0.01 for all). Compared with the control group, the propofol group had a decrease in the number of grooming sessions, cross grid sessions, and standing sessions, while the central grid stay time was prolonged(P<0.01 for all); Compared with the propofol group, the 8-Br-cAMP+propofol group showed an increase in grooming frequency, cross grid frequency, and standing frequency, while the central grid residence time was shortened(P<0.01). Compared with the control group, the MDA level in the propofol group increased while the SOD level decreased(P<0.01 for all); Compared with the propofol group, the 8-Br-cAMP+propofol group showed a decrease in MDA levels and an increase in SOD levels(all P<0.01). Compared with the control group, the mRNA expression levels of cAMP and CREB in the propofol group decreased(P<0.01); Compared with the propofol group, the expression levels of cAMP and CREB mRNA in the 8-Br-cAMP+propofol group increased(P<0.01). Compared with the control group, the relative expression levels of cAMP and CREB proteins in the propofol group decreased(P<0.01); Compared with the propofol group, the relative expression levels of cAMP and CREB proteins in the 8-Br-cAMP+propofol group increased(P<0.01). Conclusion Activating the cAMP/CREB signaling pathway can alleviate cognitive impairment and memory decline caused by propofol anesthesia, and its mechanism may be related to the regulation of oxidative stress response.

Report the clinical data of a case of X-linked lymphoproliferative syndrome type 2 in infants and young children with early-onset inflammatory bowel disease as the phenotype, and review the literature.

Report clinical data of a patient with lung infection caused by Lophomonas blattarum, with cough as the initial manifestation, and conduct literature review.

Childhood cough variant asthma is a special type of bronchial asthma, and the clinical symptoms of children are diverse, including dry cough, wheezing, chest tightness, shortness of breath, difficulty breathing, etc. If left untreated for a long time, it can lead to the continuous deterioration and development of the condition. With the advancement of technology, pathological examination techniques have been continuously updated and upgraded, gradually proving that airway remodeling is the reason why cough variant asthma in children is difficult to cure. Therefore, intervening in airway remodeling can improve lung function in pediatric patients and enhance treatment outcomes. As a traditional Chinese patent medicines and simple preparations preparation, anti-bronchial Syrup has its unique advantages and limitations in the treatment of children with cough variant asthma. This article reviews its mechanism in the airway remodeling of children with cough variant asthma.

Helicobacter pylori is a chronic infectious pathogen with a high infection rate worldwide, which is related to the occurrence of many diseases inside and outside the stomach. Currently, the specific pathogenic mechanism of H. pylori associated gastritis(HAG) is not fully understood, and some reasons are related to the stimulation of multiple cytokines in the body after H. pylori infection. Cytokines play an important role in controlling infection and maintaining the development of chronic inflammatory response. Analyzing the cytokine response during H. pylori infection is key to understanding how gastric inflammatory response is regulated and is related to pathology and disease outcomes. The article provides a review of the research progress on cytokines involved in HAG.