Glucagon-like peptide-1 receptor agonists(GLP-1 RAs) have been widely used in the management of type2 diabetes mellitus(T2 DM) and obesity. Numerous clinical trials have confirmed their cardioprotective effects in patients with heart failure(HF).As a representative GLP-1 RA, semaglutide has demonstrated benefits in various cardiovascular events in multiple large-scale cardiovascular outcome trials(CVOTs). Therefore, this study systematically summarizes the clinical trial and basic research evidence regarding the cardioprotective mechanisms of semaglutide in heart failure, aiming to provide a reference for exploring new therapeutic approaches in patients with heart failure.

Amyotrophic lateral sclerosis(ALS) is a fatal disease characterized by the progressive degeneration of motor neurons. Autosomal dominant mutations in the Fused in Sarcoma(FUS) gene, which encodes a DNA and RNA-binding protein, are one of the causes of ALS. Approximately 2.8% of familial ALS cases and some sporadic ALS cases are associated with FUS mutations, and this association is more common in the Asian population. Compared with other forms of ALS, FUSmutation-associated ALS(FUS-ALS) is characterized by early onset and rapid progression, thus attracting increasing attention in clinical research. This article discusses the research progress on its potential pathogenic mechanisms around five key dimensions: nuclear homeostasis, RNA processing, neuronal function, stress response, and metabolic balance, with the aim of providing insights for the treatment of FUS-ALS.

The technique of unilateral laminotomy for bilateral decompression(ULBD) is a minimally invasive technique widely used in clinical practice in recent years. It has unique advantages in treating degenerative diseases such as lumbar spinal stenosis and lumbar disc herniation. Nevertheless, research reports on this technique in China are relatively scarce compared to those abroad. The most significant difference compared to previous intervertebral foramen endoscopic techniques is that a unilateral approach from the back of the vertebral body is used to achieve complete decompression of the dural sac, fully preserving the stability of the patient' s spine after surgery, reducing postoperative complications, reducing intraoperative bleeding, and accelerating postoperative health. Its significant advantages have attracted widespread attention from many spinal surgeons, leading to further research and clinical application of this technology. The purpose of this article is to summarize the clinical application process of The technique of unilateral laminotomy for bilateral decompression. It is descovered that this technology is not limited to the treatment of lumbar degenerative diseases, but can also be applied to cervical and thoracic degenerative diseases. However, there are still a few postoperative complications, and further improvement is required doing better clinical efficacy.

Cancer recurrence and metastasis remain a difficult problem in current treatment, and cancer transmission is a necessary pathway for cancer recurrence and metastasis. Chinese medical master Professor Li Diangui put forward "turbid toxicity of malignant tumor" on the basis of "turbid toxicity theory" and combined with clinical experience, put forward that "turbid toxicity of malignant tumor" is the key to the pathogenesis of malignant tumor. Based on this, this article is based on passing away, and deeply explores the mechanism of "turbid toxicity of malignant tumor" in the progression of cancer recurrence and metastasis. It applies passing away theory and "turbid toxicity of malignant tumor" to prevent cancer recurrence and metastasis, enriching the oncological connotation of turbidity theory, and providing ideas for clinical prevention and treatment of cancer recurrence and metastasis.