ObjectiveTo investigate the relationship between serum C-X-C motif chemokine receptor 7(CXCR7), serum/glucocorticoid-regulated kinase 1(SGK1) levels and poor prognosis after acute myocardial infarction(AMI) percutaneous coronary intervention(PCI).MethodsOne hundred AMI patients who underwent PCI in the Emergency Department of the Second Affiliated Hospital of Nanjing Medical University from September 2020 to December 2022 were selected as the AMI group and 50 healthy medical check-ups in the hospital during the same period as the healthy control group, and the AMI patients were classified into 30 cases in the poor-prognosis subgroup and 70 cases in the good-prognosis subgroup according to the prognosis at 1 year after PCI. Serum CXCR7 and SGK1 levels were detected by enzyme-linked immunosorbent assay; multifactorial logistic regression was used to analyze the influencing factors of poor prognosis after PCI in patients with AMI; and a receiver operating characteristic(ROC) curve was established to evaluate the predictive value of serum CXCR7 and SGK1 levels for poor prognosis after PCI in patients with AMI.ResultsCompared with the healthy control group, serum CXCR7 levels were decreased and SGK1 levels were increased in the AMI group(t/P=9.613/<0.001, 9.955/<0.001); the incidence rate of poor prognosis at 1 year after PCI in 100 patients with AMI was 30.00%(30/100); and compared with the subgroup with a good prognosis, the subgroup with a poor prognosis had a decreased serum CXCR7 levels were decreased and SGK1 levels were increased(t/P=6.254/<0.001, 5.329/<0.001). Multifactorial logistic regression showed that high Gensini score, KILLIP classification ≥ grade Ⅲ, and elevated SGK1 were independent risk factors for poor prognosis after PCI in patients with AMI[OR(95%CI)=1.071(1.025-1.119), 4.501(1.172-17.282), 1.132(1.046-1.224)], and elevated CXCR7 was an independent protective factor[OR(95%CI)=0.956(0.926-0.987)]. The AUCs of serum CXCR7, SGK1, and the combination of the two for predicting poor prognosis of PCI in patients with AMI were 0.794, 0.779, and 0.902, respectively, and the AUCs of the combination of the two were greater than those predicted by the serum CXCR7 and SGK1 levels alone(Z/P=3.062/0.002, 2.930/0.003).ConclusionReduced serum CXCR7 levels and increased SGK1 levels in AMI patients are independently associated with their poor prognosis after PCI, and the combination of the two has a high predictive value for them.

ObjectiveTo investigate the relationship between serum zinc and vitamin E and the degree of condition and prognosis of patients with traumatic craniocerebral injury(TBI).MethodsOne hundred and thirty five TBI patients admitted to the Department of Neurosurgery of the Affiliated Hospital of Yan'an University from January 2020 to August 2023 were selected as the TBI group, and the TBI patients were classified into the mild TBI group(GCS score of 13 to 15, 54 cases), the moderate TBI group(GCS score of 9 to 13, 45 cases), and the severe TBI group(GCS score 3 to 8, 36 cases), TBI patients were divided into poor prognosis group(35 cases) and good prognosis group(100 cases) based on 90d prognosis, and another 100 physically healthy people in the time period were selected as the control group. Serum zinc and vitamin E levels were measured by zinc colorimetry and high-performance liquid chromatography. To compare the serum zinc and vitamin E levels between the TBI group and the control group and TBI patients with different degrees of disease, and to analyze the correlation between serum zinc and vitamin E levels and the Glasgow Coma Scale(GCS) by using Spearman's correlation coefficients; to incorporate the items that differed in the one-way analyses into the multifactorial logistic regression model to determine the factors that affect the poor prognosis of the TBI patients; and to plot the receiver operating characteristic(ROC) curves to evaluate the predictive value of serum zinc and vitamin E levels on 90d death in patients with TBI.ResultsCompared with the control group, serum zinc and vitamin E levels were significantly lower in the TBI group(t/P=10.836/<0.001, 10.160/<0.001); patients' serum zinc and vitamin E levels were higher in the mild TBI subgroup than in the moderate TBI subgroup than in the severe TBI subgroup(F/P=41.858/<0.001, 104.911/<0.001); the incidence of 90d poor prognosis in 135 TBI patients was 25.93%(35/135) as of November 2023 at follow-up; serum zinc and vitamin E levels were positively correlated with GCS scores(rs=0.709/<0.001, 0.698/<0.001). Increased GCS score, elevated zinc, and elevated vitamin E were independent protective factors for poor prognosis in patients with TBI[OR(95%CI)=0.809(0.690-0.950), 0.706(0.590-0.845), 0.726(0.599-0.880)],and abnormal basal pool and midline shift ≥5 mm were independent risk factors for poor prognosis in patients with TBI [OR(95%CI)= 5.989(1.492-24.036), 3.378(1.045-10.922)]. The AUCs of serum zinc and vitamin E levels and the combination of the two for predicting poor prognosis in patients with TBI were 0.783, 0.774, and 0.856, respectively, and the AUCs of the combination of the two were greater than those predicted by serum zinc and vitamin E levels alone(Z/P=2.580/0.010, 2.727/0.006).ConclusionReduced serum zinc and vitamin E levels in patients with TBI are associated with increased degree of disease and poor prognosis, and the combination of the two has good predictive value for poor prognosis in patients with TBI.

ObjectiveExploring the predictive value of platelet-to-lymphocyte ratio(PLR) combined with thromboelastography(TEG) for postoperative deep vein thrombosis(LDVTE) in patients with spontaneous intracerebral hemorrhage.MethodsThe clinical data of 83 patients with spontaneous intracerebral hemorrhage admitted to the Department of Neurology of the First Affiliated Hospital of Xinjiang Medical University from June 2020 to June 2023 were continuously selected. According to the occurrence of LDVTE, the patients were divided into thrombosis group(n=19) and non-thrombosis group(n=64). PLR values and TEG data were compared and analyzed. The correlation between PLR and TEG related indicators was analyzed. The receiver operating curve(AUC) of PLR, TEG and their combination was drawn and the predictive value of each index was evaluated.ResultsThe PLR value, α Angle and MA value in the thrombosis group were significantly higher than those in the non-thrombosis group(t/P=6.225/<0.001,4.290/<0.001,3.596/<0.001), K value and R value were significantly lower than those of non-thrombosis group(t/P=3.847/<0.001,3.281/0.002); PLR was positively correlated with α Angle and MA(r/P=0.402/<0.001,0.624/<0.001). And negatively correlated with K value(r/P=-0.320/0.003). There was no significant correlation with R value(r/P=-0.104/0.349). The AUC of PLR, α Angle, MA value, K value, R value and the combination of the five factors to predict LDVTE after surgery were 0.789, 0.782, 0.792, 0.795, 0.737, 0.919, respectively, and the combination of the five factors was significantly better than their individual prediction efficacy(Z/P=-2.627/0.009,-3.007/0.002,-1.999/0.046,-2.092/0.036,-3.256/0.001).ConclusionPLR and TEG are both related to LDVTE in patients after cerebral hemorrhage surgery, which can be used as reference indicators to predict the occurrence of LDVTE. PLR combined with TEG has a higher predictive value.

ObjectiveTo investigate the correlation between serum long-chain non-coding RNA(LncRNA)-metastasis-adenocarcinoma metastasis-associated transcript 1(MALAT1), LncRNA-X inactivation specific transcript(XIST) and in-stent restenosis(ISR) within 1 year after stenting in patients with lower extremity arteriosclerosis obliterans(LEASO).MethodsOne hundred and forty-seven LEASO patients who underwent stent implantation in the Department of Vascular Surgery of the Affiliated Cancer Hospital of Inner Mongolia Medical University from January 2018 to December 2022 were selected as the study subjects, and they were divided into the ISR group(41 cases) and the no-ISR group(106 cases) based on the occurrence of ISR within 1 year, and the real-time fluorescence quantitative PCR was used to detect the postoperative serum LncRNA-MALAT1, LncRNA-XIST levels; the correlation between serum LncRNA-MALAT1 and LncRNA-XIST levels and lumen diameter reduction rate in LEASO patients was analyzed by Pearson's method, the factors of ISR within 1 year after stent implantation in LEASO patients were analyzed by multifactorial logistic regression, and ROC curves were plotted to analyze the serum LncRNA-MALAT1, The predictive value of LncRNA-XIST levels for ISR within 1 year after stenting in LEASO patients.ResultsAt 1-year follow-up, the incidence of ISR after stenting was 27.89%(41/147) in 147 LEASO patients; serum LncRNA-MALAT1 and LncRNA-XIST levels were elevated in the ISR group compared with the no-ISR group(t/P=5.949/<0.001, 5.927/<0.001); Pearson's correlation showed a positive correlation between serum LncRNA-MALAT1 and LncRNA-XIST levels and the rate of lumen diameter reduction in LEASO patients(r/P=0.596/<0.001, 0.588/<0.001); Multifactorial logistic regression showed that diabetes mellitus and elevated C-reactive protein, LncRNA-MALAT1, and LncRNA-XIST were independent risk factors for ISR within 1 year of stent implantation in patients with LEASO[OR(95% CI)=3.185(1.155-8.781), 1.187(1.003-1.404), 1.433(1.199-1.713), 1.575(1.242-1.998)]; The ROC curve showed that the area under the curve for the combined serum LncRNA-MALAT1 and LncRNA-XIST levels predicting ISR within 1 year after stent implantation in LEASO patients was 0.906, which was greater than that predicted by the serum LncRNA-MALAT1 and LncRNA-XIST levels alone, which was 0.799 and 0.786(Z/P=3.176/0.002, 3.513/<0.001).ConclusionElevated serum LncRNA-MALAT1 and LncRNA-XIST levels after stent implantation in LEASO patients are independent risk factors for ISR within 1 year, and the combination of serum LncRNA-MALAT1 and LncRNA-XIST levels has a high predictive value for ISR within 1 year after stent implantation in LEASO patients.

ObjectiveTo evaluate the diagnostic and prognostic value of serum found in inflammatory zone 2(FIZZ2) in acute exacerbation of chronic obstructive pulmonary disease(AECOPD) with respiratory failure(RF).MethodsOne hundred and eighty-six cases of AECOPD patients with RF treated in the Emergency Department of Jiayuguan First People's Hospital from February 2020 to February 2023 were selected as the RF group and 186 cases of AECOPD patients without RF were selected as the non-AF group. Serum levels of FIZZ2, procalcitonin(PCT) and C-reactive protein(CRP) were determined by enzyme-related immunosorbent assay. Survival of patients with AECOPD combined with RF within 60 days was analyzed. According to survival, patients with AECOPD combined with RF were divided into death subgroup(56 cases) and survival subgroup(130 cases). Pearson correlation analysis was conducted to analyze the correlation between FIZZ2 and PCT and CRP. The factors affecting the prognosis of AECOPD patients with RF and the value of FIZZ2 in predicting the prognosis of AECOPD patients with RF were analyzed.ResultsThe levels of serum FIZZ2, PCT and CRP in RF group were higher than those in non-RF group(t/P=58.968/< 0.001, 16.260/< 0.001, 10.382/< 0.001). The levels of serum FIZZ2, PCT and CRP in death subgroup were higher than those in survival subgroup(t/P=5.164/< 0.001, 4.141/< 0.001, 12.354/< 0.001). Serum FIZZ2 levels were positively correlated with PCT and CRP levels in patients with AECOPD and RF(r/P=0.452/< 0.001, 0.427/< 0.001). High PCT, high FIZZ2 and high APACHE Ⅱ scores were risk factors for poor prognosis in patients with AECOPD and RF[OR(95%CI)=1.680(1.111-2.541), 1.921(1.147-3.217), 2.547(1.278-5.078)]. Serum FIZZ2, PCT, CRP and combined to predict the prognosis of patients with AECOPD combined RF AUC were 0.842, 0.794, 0.846, 0.925, combined slightly better than their individual predictions(Z/P=3.465/0.001, 2.399/0.016, 2.194/0.028).ConclusionThe increase of serum FIZZ2 level in patients with AECOPD combined with RF is associated with poor prognosis, and has a high value in predicting the prognosis of patients with AECOPD combined with RF.