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Progress in the study of the role of coagulation dysfunction in the pathogenesis of sepsis-induced myocardial injury
Author: Liao Ximing Yang Guohui Guizhou
keyword:Sepsis ; Myocardial injury ; Coagulation dysfunction ; Pathogenesis
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to various infections, with persistently high global incidence and mortality rates. Myocardial injury induced by sepsis is among its most severe complications, with its complex pathophysiological mechanisms involving excessive inflammatory responses, oxidative stress, mitochondrial damage, cell apoptosis, autophagy, and coagulation dysfunction. Coagulation dysfunction plays an indispensable role, where its early recognition and treatment are crucial for improving cardiac function and prognosis in patients. The article reviews the role of coagulation dysfunction in sepsis-induced myocardial injury(SIMI), discussing its potential as a new therapeutic target, providing a reference for clinical practice.
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Research progress on the pathogenesis of sepsis-associated acute kidney injury
Author: Yan Yating Tan Ruimin Fu You Du Quansheng
keyword:Sepsis ; Acute kidney injury ; Pathogenesis
Sepsis is a common and critical disease in clinical practice, which often leads to multi-organ dysfunction and even life-threatening in severe cases. As one of the most commonly affected target organs of sepsis, sepsis-associated acute kidney injury(SAKI) has a more serious impact on the prognosis of patients. The pathogenesis of SAKI is very complex, involving immune inflammatory response, oxidative stress, apoptosis, endothelial cell dysfunction, hemodynamic abnormalities, mitochondrial quality control disorders and other aspects, so the pathogenesis of SAKI has not been fully elucidated. This article discusses the research progress on the pathogenesis of SAKI and briefly reviews it, in order to find new targets for the effective treatment of SAKI.
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Research progress in the signal interaction mechanism between gastric cancer cells and the tumor microenvironment
Author: Liu Yaqin Deng Ke Liu Qi Peng Pailan
keyword:Gastric cancer ; Tumor microenvironment ; Signal interaction mechanism ; Immune regulation
Gastric cancer, as one of the common upper gastrointestinal malignancies, often misses the optimal treatment window as patients tend to progress to advanced local stages or systemic metastasis at the time of initial diagnosis due to a lack of specific symptoms in the early stage. During the occurrence and development of gastric cancer, the tumor acts not only as an uncontrollable cell proliferation disease but also as a disorder resulting from a disturbed microenvironment. A series of studies have revealed that the tumor microenvironment plays a significant role in the initiation, progression, and metastasis of the tumor. This article provides a review of the recent research advancements in the interaction mechanisms between gastric cancer cells and the tumor microenvironment signaling.
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Chromatin remodeling: new perspectives in disease mechanisms and therapy
Author: Chen Hui Wang Jishi
keyword:Chromatin remodeling ; Disease ; Mechanisms ; Treatment
Chromatin remodeling is a critical mechanism for regulating gene expression and maintaining genomic stability. In recent years, with the advancement of epigenetics research, the role of chromatin remodeling in the pathogenesis, progression, and treatment of diseases has garnered widespread attention. Particularly in diseases such as cancer, neurodegenerative disorders, and developmental abnormalities, the aberrant activity of chromatin remodeling factors has been demonstrated to be closely associated with disease mechanisms.
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Research progress of inhibiting organ fibrosis by regulating TGF-β signaling pathway
Author: Li Pengyu Xia Yu Li Fei
keyword:Scutellarin ; TGF-β signaling pathway ; Organ fibrosis
In recent years, significant advancements have been made in the study of Scutellarin's role in inhibiting organ fibrosis. The article delves into the mechanisms by which Scutellarin regulates organ fibrosis through the TGF-β signaling pathway. It provides a detailed discussion of Scutellarin's inhibitory effects on liver, lung, heart, and kidney fibrosis, offering profound insights into the mechanisms underlying Scutellarin's therapeutic potential in treating organ fibrosis diseases.