Homepage
《YiNanBing ZaZhi》2024 Vol.22,No.08
  • The clinical significance of serum SPD and mannose in predicting the prognosis of patients with acute respiratory distress syndrome
    Author:​ Wei Yaona Duan Wei Liang Lei Wang Pengfei keyword:Acute respiratory distress syndrome ; Surfactant protein D ; Mannose ; Prognosis ; Predictive value
    ObjectiveThe purpose of this study is to investigate the predictive value of serum surfactant protein D(SPD) and mannose levels in patients with acute respiratory distress syndrome(ARDS) in terms of prognosis.MethodsA retrospective collection was conducted on 112 ARDS patients(ARDS group) who received treatment in Respiratory and Critical Care Medicine Department of Shanxi Norman Bethune Hospital(Shanxi Academy of Medical Sciences) from February 2020 to March 2022. According to the severity of the ARDS patients, they were divided into mild subgroup(n=42), moderate subgroup(n=38), and severe subgroup(n=32), as well as survival subgroup(n=81) and death subgroup(n=31) based on the prognosis. 60 healthy individuals were taken as the healthy control group. Enzyme-linked immunosorbent assay was used to detect serum SPD and mannose levels. The prognostic factors of ARDS patients and the prognostic evaluation value of serum SPD and mannose were analyzed using statistical analysis.ResultsThe serum SPD and mannose levels in the ARDS group were(162.21 ± 21.78) μ g/L and(130.65 ± 19.90) ng/L, respectively, lower than those in the healthy control group(252.34 ± 45.70) μ g/L and(227.14 ± 37.21) ng/L(t=26.641, 22.185,P<0.001). The serum levels of SPD and mannose in the mild, moderate, and severe subgroups decreased significantly in sequence(F/P=142.650/<0.001,84.621/<0.001). Compared with the healthy control group, the SOFA score and APACHE Ⅱ score of ARDS patients in the death group were higher, while serum SPD and mannose were lower(t/P=4.366/<0.001,6.470/<0.001,6.099/<0.001,8.586/<0.001). SOFA score and APACHE Ⅱ score were risk factors affecting the 28 day mortality prognosis of ARDS patients, while serum SPD and mannose were protective factors[OR(95%CI)=1.423(1.088-1.862),1.511(1.140-2.004),0.564(0.445-0.715),0.618(0.474-0.807)]. The area under the curve(AUC) for predicting the 28 day mortality prognosis of ARDS patients with serum SPD and mannose combination was 0.949, which was greater than single indicator detection of 0.826 and 0.895(Z=5.021, 4.432,P<0.001, 0.002).ConclusionThe serum levels of SPD and mannose in ARDS patients decrease, which are correlated with the severity of the patient's condition. The combination of serum SPD and mannose has good predictive value for the prognosis of ARDS patients.
  • Predictive value of GAS, MTL, PGs and Ghrelin levels before resection of gastric polyps on postoperative recurrence of gastric polyps
    Author:​ Yang Linghe Zhang Mengxia Qiao Kun Gao Feng keyword:Gastric polyps ; Gastrointestinal hormones ; Postoperative recurrence ; Predictive value
    ObjectiveTo explore the predictive value of preoperative gastrin(GAS), motilin(MTL), pepsinogen(PGs) and Ghrelin levels in postoperative recurrence of gastric polyps.MethodsOne hundred and twenty-eight patients who underwent gastric polypectomy at People's Hospital of Xinjiang Uygur Autonomous Region between May 2019 and December 2021 were included in this study. All patients were followed up for a duration of 2 years. Based on the recurrence of gastric polyps, they were categorized into two groups: non-recurrent group(n=86) and recurrent group(n=42). The general clinical information, as well as surgical and pathological data, were collected and compared between the two groups. Additionally, the levels of gastrointestinal hormones such as GAS, MTL, PGs, and Ghrelin were measured and compared prior to the operation. Spearman correlation analysis, univariate, and multivariate Logistic regression analysis were conducted to identify the risk factors for postoperative recurrence of gastric polyps. Furthermore, the independent and combined predictive value for gastric polyp recurrence was evaluated using a receiver operating characteristic(ROC) curve.ResultsThe recurrent group showed significantly longer duration for endoscopic operations, a higher prevalence of multiple gastric polyps, and a higher proportion of patients with a maximum gastric polyp diameter > 2cm compared to the non-recurrent group(Z/χ2/P=3.453/0.001, 5.965/0.015, 7.342/0.007). Additionally, the average preoperative serum levels of GAS, MTL, PGⅠ, PG Ⅱ, and Ghrelin were significantly higher in the recurrent group compared to the non-recurrent group(t/P=7.736/<0.001, 5.984/<0.001, 6.326/<0.001, 6.420//<0.001, 6.326/<0.001). spearman="" correlation="" analysis="" showed="" that="" endoscopic="" operation="" multiple="" gastric="" maximum="" diameter="" of="" polyps="">2 cm, serum GAS, MTL, PG Ⅰ, PG Ⅱ and Ghrelin were positively correlated with postoperative recurrence of gastric polyps(r/P=0.306/<0.001, 0.216/0.014, 0.239/0.006, 0.563/<0.001, 0.453/<0.001, 0.486/<0.001, 0.484/<0.001, 0.458/<0.001). Multivariate Logistic regression analysis, indicated that elevated serum levels of GAS, MTL, PG Ⅰ, PG Ⅱ, and Ghrelin were significant risk factors for recurrence in postoperative patients with gastric polyps[OR(95%CI)=1.394(1.086-1.789), 1.098(1.031-1.169), 1.081(1.026-1.139), 1.793(1.264-2.542), 1.059(1.007-1.114)]. Furthermore, the predictive efficacy of serum levels of GAS, MTL, PG Ⅰ, PG Ⅱ, and Ghrelin in determining disease recurrence after gastric polypectomy was noteworthy, with improved accuracy when combined together(Z=3.014/<0.001, 3.666/<0.001, 3.354/<0.001, 3.355/<0.001, 3.462/<0.001).ConclusionThe presence of gastric polyps in postoperative patients has been found to have a significant correlation with the levels of serum GAS, MTL, PGs, and Ghrelin. In order to predict and prevent the recurrence of gastric polyps, it is clinically important to closely monitor the levels of gastrointestinal hormones in these patients. This timely intervention can greatly improve the prognosis and overall outcome.
  • Correlation of serum LncRNA Dlx6os1 and LncRNA TUG1 levels with renal injury and prognosis in elderly patients with diabetic nephropathy
    Author: Zhao Liaoliao Cao Li Chang Luyuan Liu Yuyu Si Yafang keyword:Diabetic nephropathy ; Long non-coding RNA ; Distal-less homeobox 6 antisense RNA 1 ; Taurine up-regulated gene 1 ; Kidney injury ; Prognosis ; Elderly
    ObjectiveTo investigate the correlation between serum long non-coding RNA(LncRNA) distal-less homeobox 6 antisense RNA 1(Dlx6os1), LncRNA taurine up-regulated gene 1(TUG1) levels and renal injury and prognosis in elderly diabetic nephropathy(DN) patients.MethodsTwo hundred and one elderly DN patients admitted to the Department of Nephrology, Yulin Hospital, the First Affiliated Hospital of Xi'an Jiaotong University from January 2019 to January 2021 were selected as the DN group, 112 patients with pure T2DM during the same period as the pure T2DM group, and 105 healthy elderly people with physical examination during the same period as the control group, and the elderly DN patients were divided into a poor prognosis subgroup(61 cases) according to the 3-year prognosis and a good prognosis subgroup(140 cases). The levels of serum LncRNA Dlx6os1, LncRNA TUG1 and renal injury indicators[estimated glomerular filtration rate(eGFR), urinary albumin creatinine ratio(UACR)]were detected; the correlation between the levels of serum LncRNA Dlx6os1 and LncRNA TUG1 and renal injury of the elderly patients with DN was analyzed using Spearman's correlation coefficient; a multifactorial unconditional Logistic regression model to analyze the influence factors with the elderly DN patients' prognosis as the dependent variable, a multifactorial unconditional Logistic regression model was established to analyze the influencing factors, and the predictive value of serum LncRNA Dlx6os1 and LncRNA TUG1 levels was evaluated by plotting the receiver operating characteristics(ROC) curves.ResultsSerum LncRNA Dlx6os1 and UACR levels were sequentially increased and serum LncRNA TUG1 and eGFR were sequentially decreased in the control, T2DM-only, and DN groups(F/P=870.484/<0.001, 566.671/<0.001, 271.117/<0.001, 196.722/<0.001); Spearman's correlation showed that serum LncRNA Dlx6os1 levels were negatively correlated with eGFR and positively correlated with UACR in elderly DN patients(r/P=-0.816/<0.001,0.809/<0.001), and serum LncRNA TUG1 levels were positively correlated with eGFR and negatively correlated with UACR(r/P=0.832/<0.001,-0.806/<0.001); Follow-up as of January 2024, the incidence of poor prognosis in 201 cases of elderly DN patients was 30.35%(61/201); multifactorial unconditional logistic regression showed that chronic kidney disease stage 4, high UACR, and high LncRNA Dlx6os1 were the independent risk factors for poor prognosis in elderly DN patients[OR(95%CI)=5.758(1.480-22.401), 1.013(1.005-1.022), 1.426(1.201-1.693)], and high eGFR and high LncRNA TUG1 were the independent protective factors[OR(95%CI)=0.958(0.939-0.978), 0.418(0.254-0.689)]; ROC curves showed that the AUCs of serum LncRNA Dlx6os1, LncRNA TUG1, and the combination of the two for predicting poor prognosis in elderly DN patients were 0.774, 0.777, and 0.852, respectively, and the AUCs for the combination of the two were the largest(Z/P=2.930/0.003, 3.335/0.001).ConclusionElevated serum LncRNA Dlx6os1 levels and reduced LncRNA TUG1 levels in elderly DN patients are associated with increased risk of aggravated renal injury and poor prognosis, and serum LncRNA Dlx6os1 in combination with LncRNA TUG1 levels are of high value for predicting poor prognosis in elderly DN patients.
  • The expression of serum Xenin-25 and CTRP12 in patients with gestational diabetes and the effects on pregnancy outcome
    Author:​ Zhang Jie Wang Jing Liu Qihang Zhu Jing Wu Bin Chen Xiaofen keyword:Gestational diabetes ; Xenin-25 ; Complement C1 tumor necrosis factor related protein 12 ; Pregnancy outcome
    ObjectiveTo analyze the relationship between serum neurotensin related peptide(Xenin-25), complement C1 tumor necrosis factor related protein 12(CTRP12) and pregnancy outcome in patients with gestational diabetes mellitus(GDM).MethodsNinety-two GDM patients diagnosed and treated in the Reproductive Medicine Department of the Affiliated Hospital of North Sichuan Medical College from February 2021 to February 2022 were selected as the GDM group. According to the presence or absence of adverse pregnancy outcomes, they were divided into poor prognosis subgroup(n=34) and good prognosis subgroup(n=58). A total of 50 healthy pregnant women in the same period were enrolled as the normal pregnancy group. Serum Xenin-25 and CTRP12 were detected by enzyme-linked immunosorbent assay. Pearson correlation analysis was used to analyze the correlation between serum Xenin-25, CTRP12 and glucose metabolism indexes. Multivariate Logistic regression was used to analyze the factors affecting adverse pregnancy outcomes in GBM patients. Receiver operating characteristic curve was used to evaluate the predictive value of serum Xenin-25 and CTRP12 for pregnancy outcome.ResultsThe levels of serum Xenin-25 and CTRP12 in the GDM group were lower than those in the control group, while the levels of fasting plasma glucose(FPG), glycosylated hemoglobin(HbA1c), fasting insulin(FINS) and homeostasis model assessment of insulin resistance(HOMA-IR) were higher than those in the control group(t/P=16.046/<0.001,22.114/<0.001,11.510/<0.001,13.666/<0.001,12.101/<0.001, 14.413/<0.001). Serum Xenin-25 and CTRP12 levels were negatively correlated with FPG, HbA1c, FINS and HOMA-IR in GDM group(Xenin-25:r/P=-0.665/<0.001,-0.598/<0.001,-0.567/<0.001,-0.702/<0.001; CTRP12:r/P=-0.579/<0.001,-0.622/<0.001,-0.667/<0.001,-0.725/<0.001); Compared with the good prognosis subgroup, the poor prognosis subgroup had lower serum CTRP12 and Xenin-25 and higher HOMA-IR(t/P=6.783/<0.001, 17.997/<0.001, 15.146/<0.001). High serum CTRP12 and Xenin-25 were independent protective factors for adverse pregnancy outcomes in GDM patients[OR(95%CI)=0.646(0.499-0.837), 0.619(0.465-0.824)],and high HOMA-IR was risk factor[OR(95%CI)=1.353(1.110-1.649)]. The AUC of serum Xenin-25, CTRP12 and their combination for predicting adverse pregnancy outcomes in GDM patients were 0.828, 0.815 and 0.870, respectively. The combination of xenin-25 and CTRP12 was superior to their individual prediction efficacy(Z/P=4.113/0.003,4.327/0.001).ConclusionGDM patients have decreased serum CTRP12 and Xenin-25 levels, which are involved in the disease process of GDM. The combination of CTRP12 and Xenin-25 has a high evaluation value for adverse pregnancy outcomes in GDM patients.
  • Effects of febuxostat combined with indomethacin on serum uric acid, pain and oxidative stress in gouty arthritis patients
    Author: Pan Aiping Jin Xiaoping Jiazireya Zaiyinati keyword:Gouty arthritis ; Febuxostat ; Indomethacin ; Uric acid ; Pain ; Oxidative stress
    ObjectiveTo investigate the effect of febuxostat combined with indomethacin on serum uric acid, pain and oxidative stress in gouty arthritis patients.MethodsA total of 86 patients with gouty arthritis were included in our hospital. They were randomly divided into observation group(n=43) and control group(n=43). Patients in the control group received febuxostat tablets orally, and patients in the observation group received indomethacin tablets orally on this basis. All patients continued treatment for 1 month. Visual analogue scale(VAS) was used to assess the degree of joint pain before treatment, 2 weeks and 1 month after treatment. Serum creatinine(SCr), uric acid(UA), urea nitrogen(BUN) and other renal function indexes were compared between the two groups before and after treatment. Serum interleukin 1β(IL-1β), NACHT-LR-PYD-containing protein3(NALP3), tumor necrosis factor-α(TNF-α) and other inflammatory markers; Glutathione peroxidase(GSH-Px), superoxide dismutase(SOD) and malondialdehyde(MDA) in serum were related to oxidative stress. Clinical efficacy and adverse event incidence were evaluated.ResultsThe total effectiveness rate of the observation group stood at 88.37%, outshining the control group's rate of 69.77%(χ2/P=4.497/0.034). Following a 2-week treatment period, both groups witnessed a decrease in average VAS scores compared to pre-treatment levels(t/P=5.324/<0.001). Moreover, the observation group displayed lower average serum levels of UA and Scr in comparison to the control group(t/P=3.081/0.003, 2.692/0.009). In addition, the observation group exhibited reduced average serum levels of IL-1 β and NALP3 post-treatment, surpassing both pre-treatment levels and those of the control group(t/P=5.587/<0.001, 2.465/0.016). Conversely, the average serum levels of GSH-Px and SOD saw an increase compared to pre-treatment levels and exceeded those of the control group. Meanwhile, the average serum MDA levels decreased, falling below the control group's levels(t/P=3.709/<0.001, 3.655/<0.001, 3.653/<0.001). Additionally, the observation group experienced a shorter average pain disappearance time than the control group(t/P=4.025/<0.001). Furthermore, the total occurrence of drug-related adverse events was lower in the observation group, albeit the variance was not deemed statistically significant in comparison to the control group(11.63% vs 18.60%,χ2/P=0.816/0.366).ConclusionFebuxostat combined with indomethacin has more significant effect on renal function improvement in patients with gouty arthritis. Meanwhile, the combination therapy can effectively reduce the inflammatory level and oxidative stress level of patients, which is conducive to improving the clinical efficacy of patients and has good clinical safety. It has certain clinical application value for patients with gouty arthritis.